Color Cherenkov imaging of clinical radiation therapy

Color vision is used throughout medicine to interpret the health and status of tissue. Ionizing radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect, and this light is attenuated by tissue features as it leaves the body. In this study, a novel...

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Autores principales: Alexander, Daniel A., Nomezine, Anthony, Jarvis, Lesley A., Gladstone, David J., Pogue, Brian W., Bruza, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569159/
https://www.ncbi.nlm.nih.gov/pubmed/34737264
http://dx.doi.org/10.1038/s41377-021-00660-0
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author Alexander, Daniel A.
Nomezine, Anthony
Jarvis, Lesley A.
Gladstone, David J.
Pogue, Brian W.
Bruza, Petr
author_facet Alexander, Daniel A.
Nomezine, Anthony
Jarvis, Lesley A.
Gladstone, David J.
Pogue, Brian W.
Bruza, Petr
author_sort Alexander, Daniel A.
collection PubMed
description Color vision is used throughout medicine to interpret the health and status of tissue. Ionizing radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect, and this light is attenuated by tissue features as it leaves the body. In this study, a novel time-gated three-channel camera was developed for the first time and was used to image color Cherenkov emission coming from patients during treatment. The spectral content was interpreted by comparison with imaging calibrated tissue phantoms. Color shades of Cherenkov emission in radiotherapy can be used to interpret tissue blood volume, oxygen saturation and major vessels within the body.
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spelling pubmed-85691592021-11-08 Color Cherenkov imaging of clinical radiation therapy Alexander, Daniel A. Nomezine, Anthony Jarvis, Lesley A. Gladstone, David J. Pogue, Brian W. Bruza, Petr Light Sci Appl Article Color vision is used throughout medicine to interpret the health and status of tissue. Ionizing radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect, and this light is attenuated by tissue features as it leaves the body. In this study, a novel time-gated three-channel camera was developed for the first time and was used to image color Cherenkov emission coming from patients during treatment. The spectral content was interpreted by comparison with imaging calibrated tissue phantoms. Color shades of Cherenkov emission in radiotherapy can be used to interpret tissue blood volume, oxygen saturation and major vessels within the body. Nature Publishing Group UK 2021-11-04 /pmc/articles/PMC8569159/ /pubmed/34737264 http://dx.doi.org/10.1038/s41377-021-00660-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Alexander, Daniel A.
Nomezine, Anthony
Jarvis, Lesley A.
Gladstone, David J.
Pogue, Brian W.
Bruza, Petr
Color Cherenkov imaging of clinical radiation therapy
title Color Cherenkov imaging of clinical radiation therapy
title_full Color Cherenkov imaging of clinical radiation therapy
title_fullStr Color Cherenkov imaging of clinical radiation therapy
title_full_unstemmed Color Cherenkov imaging of clinical radiation therapy
title_short Color Cherenkov imaging of clinical radiation therapy
title_sort color cherenkov imaging of clinical radiation therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569159/
https://www.ncbi.nlm.nih.gov/pubmed/34737264
http://dx.doi.org/10.1038/s41377-021-00660-0
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