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Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency

Krüppel-like factor 10 (KLF10) is a tumor suppressor in multiple cancers. In a murine model of spontaneous pancreatic adenocarcinoma (PDAC), additional KLF10 depletion accelerated distant metastasis. However, Klf10 knockout mice, which suffer from metabolic disorders, do not develop malignancy. The...

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Detalles Bibliográficos
Autores principales:	Tsai, Yi-Chih, Chen, Su-Liang, Peng, Shu-Ling, Tsai, Ya-Li, Chang, Zuong-Ming, Chang, Vincent Hung-Shu, Ch’ang, Hui-Ju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569177/ https://www.ncbi.nlm.nih.gov/pubmed/34702956 http://dx.doi.org/10.1038/s12276-021-00687-8

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