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Risky decision-making following prefrontal D1 receptor manipulation

The prefrontal dopamine D1 receptor (D1R) is involved in cognitive processes. Viral overexpression of this receptor in rats further increases the reward-related behaviors and even its termination induces anhedonia and helplessness. In this study, we investigated the risky decision-making during D1R...

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Autores principales: Beyer, Dominik K. E., Horn, Lisa, Klinker, Nadine, Freund, Nadja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569284/
https://www.ncbi.nlm.nih.gov/pubmed/34760299
http://dx.doi.org/10.1515/tnsci-2020-0187
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author Beyer, Dominik K. E.
Horn, Lisa
Klinker, Nadine
Freund, Nadja
author_facet Beyer, Dominik K. E.
Horn, Lisa
Klinker, Nadine
Freund, Nadja
author_sort Beyer, Dominik K. E.
collection PubMed
description The prefrontal dopamine D1 receptor (D1R) is involved in cognitive processes. Viral overexpression of this receptor in rats further increases the reward-related behaviors and even its termination induces anhedonia and helplessness. In this study, we investigated the risky decision-making during D1R overexpression and its termination. Rats conducted the rodent version of the Iowa gambling task daily. In addition, the methyl CpG–binding protein-2 (MeCP2), one regulator connecting the dopaminergic system, cognitive processes, and mood-related behavior, was investigated after completion of the behavioral tasks. D1R overexpressing subjects exhibited maladaptive risky decision-making and risky decisions returned to control levels following termination of D1R overexpression; however, after termination, animals earned less reward compared to control subjects. In this phase, MeCP2-positive cells were elevated in the right amygdala. Our results extend the previously reported behavioral changes in the D1R-manipulated animal model to increased risk-taking and revealed differential MeCP2 expression adding further evidence for a bipolar disorder-like phenotype of this model.
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spelling pubmed-85692842021-11-09 Risky decision-making following prefrontal D1 receptor manipulation Beyer, Dominik K. E. Horn, Lisa Klinker, Nadine Freund, Nadja Transl Neurosci Research Article The prefrontal dopamine D1 receptor (D1R) is involved in cognitive processes. Viral overexpression of this receptor in rats further increases the reward-related behaviors and even its termination induces anhedonia and helplessness. In this study, we investigated the risky decision-making during D1R overexpression and its termination. Rats conducted the rodent version of the Iowa gambling task daily. In addition, the methyl CpG–binding protein-2 (MeCP2), one regulator connecting the dopaminergic system, cognitive processes, and mood-related behavior, was investigated after completion of the behavioral tasks. D1R overexpressing subjects exhibited maladaptive risky decision-making and risky decisions returned to control levels following termination of D1R overexpression; however, after termination, animals earned less reward compared to control subjects. In this phase, MeCP2-positive cells were elevated in the right amygdala. Our results extend the previously reported behavioral changes in the D1R-manipulated animal model to increased risk-taking and revealed differential MeCP2 expression adding further evidence for a bipolar disorder-like phenotype of this model. De Gruyter 2021-11-03 /pmc/articles/PMC8569284/ /pubmed/34760299 http://dx.doi.org/10.1515/tnsci-2020-0187 Text en © 2021 Dominik K. E. Beyer et al., published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Beyer, Dominik K. E.
Horn, Lisa
Klinker, Nadine
Freund, Nadja
Risky decision-making following prefrontal D1 receptor manipulation
title Risky decision-making following prefrontal D1 receptor manipulation
title_full Risky decision-making following prefrontal D1 receptor manipulation
title_fullStr Risky decision-making following prefrontal D1 receptor manipulation
title_full_unstemmed Risky decision-making following prefrontal D1 receptor manipulation
title_short Risky decision-making following prefrontal D1 receptor manipulation
title_sort risky decision-making following prefrontal d1 receptor manipulation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569284/
https://www.ncbi.nlm.nih.gov/pubmed/34760299
http://dx.doi.org/10.1515/tnsci-2020-0187
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