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Proline Isomerization as a Key Determinant for Hsp90-Toxin Interactions
The A chains of ADP-ribosylating toxins exploit Hsp90 for translocation into the host cytosol. Here, we hypothesize that cis proline residues play a key role in toxin recognition by Hsp90. Our model is largely derived from studies on the unusual interplay between Hsp90 and the catalytic A1 subunit o...
Autores principales: | Kellner, Alisha, Cherubin, Patrick, Harper, James K., Teter, Ken |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569296/ https://www.ncbi.nlm.nih.gov/pubmed/34746036 http://dx.doi.org/10.3389/fcimb.2021.771653 |
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