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Proline Isomerization as a Key Determinant for Hsp90-Toxin Interactions

The A chains of ADP-ribosylating toxins exploit Hsp90 for translocation into the host cytosol. Here, we hypothesize that cis proline residues play a key role in toxin recognition by Hsp90. Our model is largely derived from studies on the unusual interplay between Hsp90 and the catalytic A1 subunit o...

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Detalles Bibliográficos
Autores principales: Kellner, Alisha, Cherubin, Patrick, Harper, James K., Teter, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569296/
https://www.ncbi.nlm.nih.gov/pubmed/34746036
http://dx.doi.org/10.3389/fcimb.2021.771653

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