Cargando…

Distinct Effects of Short Chain Fatty Acids on Host Energy Balance and Fuel Homeostasis With Focus on Route of Administration and Host Species

Accumulating evidence implicates gut-microbiota-derived metabolites as important regulators of host energy balance and fuel homeostasis, the underlying mechanisms are currently subject to intense research. In this review, the most important executors, short chain fatty acids, which both directly and...

Descripción completa

Detalles Bibliográficos
Autores principales: Kong, Dehuang, Schipper, Lidewij, van Dijk, Gertjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569404/
https://www.ncbi.nlm.nih.gov/pubmed/34744617
http://dx.doi.org/10.3389/fnins.2021.755845
_version_ 1784594633291988992
author Kong, Dehuang
Schipper, Lidewij
van Dijk, Gertjan
author_facet Kong, Dehuang
Schipper, Lidewij
van Dijk, Gertjan
author_sort Kong, Dehuang
collection PubMed
description Accumulating evidence implicates gut-microbiota-derived metabolites as important regulators of host energy balance and fuel homeostasis, the underlying mechanisms are currently subject to intense research. In this review, the most important executors, short chain fatty acids, which both directly and indirectly fulfill the interactions between gut microbiota and host will be discussed. Distinct roles of individual short chain fatty acids and the different effects they exert on host metabolism have long been overlooked, which compromises the process of clarifying the sophisticated crosstalk between gut microbiota and its host. Moreover, recent findings suggest that exogenously administered short chain fatty acids affect host metabolism via different mechanisms depending on the routes they enter the host. Although these exogenous routes are often artificial, they may help to comprehend the roles of the short-chain-fatty-acid mechanisms and signaling sites, that would normally occur after intestinal absorption of short chain fatty acids. Cautions should be addressed of generalizing findings, since different results have appeared in different host species, which may imply a host species-specific response to short chain fatty acids.
format Online
Article
Text
id pubmed-8569404
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85694042021-11-06 Distinct Effects of Short Chain Fatty Acids on Host Energy Balance and Fuel Homeostasis With Focus on Route of Administration and Host Species Kong, Dehuang Schipper, Lidewij van Dijk, Gertjan Front Neurosci Neuroscience Accumulating evidence implicates gut-microbiota-derived metabolites as important regulators of host energy balance and fuel homeostasis, the underlying mechanisms are currently subject to intense research. In this review, the most important executors, short chain fatty acids, which both directly and indirectly fulfill the interactions between gut microbiota and host will be discussed. Distinct roles of individual short chain fatty acids and the different effects they exert on host metabolism have long been overlooked, which compromises the process of clarifying the sophisticated crosstalk between gut microbiota and its host. Moreover, recent findings suggest that exogenously administered short chain fatty acids affect host metabolism via different mechanisms depending on the routes they enter the host. Although these exogenous routes are often artificial, they may help to comprehend the roles of the short-chain-fatty-acid mechanisms and signaling sites, that would normally occur after intestinal absorption of short chain fatty acids. Cautions should be addressed of generalizing findings, since different results have appeared in different host species, which may imply a host species-specific response to short chain fatty acids. Frontiers Media S.A. 2021-10-22 /pmc/articles/PMC8569404/ /pubmed/34744617 http://dx.doi.org/10.3389/fnins.2021.755845 Text en Copyright © 2021 Kong, Schipper and van Dijk. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kong, Dehuang
Schipper, Lidewij
van Dijk, Gertjan
Distinct Effects of Short Chain Fatty Acids on Host Energy Balance and Fuel Homeostasis With Focus on Route of Administration and Host Species
title Distinct Effects of Short Chain Fatty Acids on Host Energy Balance and Fuel Homeostasis With Focus on Route of Administration and Host Species
title_full Distinct Effects of Short Chain Fatty Acids on Host Energy Balance and Fuel Homeostasis With Focus on Route of Administration and Host Species
title_fullStr Distinct Effects of Short Chain Fatty Acids on Host Energy Balance and Fuel Homeostasis With Focus on Route of Administration and Host Species
title_full_unstemmed Distinct Effects of Short Chain Fatty Acids on Host Energy Balance and Fuel Homeostasis With Focus on Route of Administration and Host Species
title_short Distinct Effects of Short Chain Fatty Acids on Host Energy Balance and Fuel Homeostasis With Focus on Route of Administration and Host Species
title_sort distinct effects of short chain fatty acids on host energy balance and fuel homeostasis with focus on route of administration and host species
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569404/
https://www.ncbi.nlm.nih.gov/pubmed/34744617
http://dx.doi.org/10.3389/fnins.2021.755845
work_keys_str_mv AT kongdehuang distincteffectsofshortchainfattyacidsonhostenergybalanceandfuelhomeostasiswithfocusonrouteofadministrationandhostspecies
AT schipperlidewij distincteffectsofshortchainfattyacidsonhostenergybalanceandfuelhomeostasiswithfocusonrouteofadministrationandhostspecies
AT vandijkgertjan distincteffectsofshortchainfattyacidsonhostenergybalanceandfuelhomeostasiswithfocusonrouteofadministrationandhostspecies