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Changes in the Antioxidant and Mineral Status of Rabbits After Administration of Dietary Zinc and/or Thyme Extract

This study was aimed at determining the impact of organic zinc (Zn) and thyme extract (TE) administration, given alone or together for 6 weeks, on the antioxidant and mineral status (Zn, Cu, Fe, and Mn) in the plasma and tissues of growing rabbits. A total of 96 rabbits of age 35 days were randomly...

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Autores principales: Kucková, Katarína, Grešáková, L'ubomíra, Takácsová, Margaréta, Kandričáková, Anna, Chrastinová, L'ubica, Polačiková, Mária, Cieslak, Adam, Ślusarczyk, Sylwester, Čobanová, Klaudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569448/
https://www.ncbi.nlm.nih.gov/pubmed/34746281
http://dx.doi.org/10.3389/fvets.2021.740658
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author Kucková, Katarína
Grešáková, L'ubomíra
Takácsová, Margaréta
Kandričáková, Anna
Chrastinová, L'ubica
Polačiková, Mária
Cieslak, Adam
Ślusarczyk, Sylwester
Čobanová, Klaudia
author_facet Kucková, Katarína
Grešáková, L'ubomíra
Takácsová, Margaréta
Kandričáková, Anna
Chrastinová, L'ubica
Polačiková, Mária
Cieslak, Adam
Ślusarczyk, Sylwester
Čobanová, Klaudia
author_sort Kucková, Katarína
collection PubMed
description This study was aimed at determining the impact of organic zinc (Zn) and thyme extract (TE) administration, given alone or together for 6 weeks, on the antioxidant and mineral status (Zn, Cu, Fe, and Mn) in the plasma and tissues of growing rabbits. A total of 96 rabbits of age 35 days were randomly assigned to one of four treatment groups: a control group (C), a Zn group supplemented with dietary zinc (50 mg/kg), a TE group receiving thyme extract applied in drinking water (1 ml/L), and a Zn + TE group treated with both additives. Lipid peroxidation in the plasma was influenced by Zn intake and in the kidney was affected by both the Zn and TE treatment (P < 0.05). Zn supplementation led to a significant increase in glutathione peroxidase activity (P = 0.017), total antioxidant capacity (P = 0.009) and total thiol groups level (P = 0.047) in the kidney, with the highest values occurring in rabbits receiving the combination Zn + TE. Administration of TE influenced Zn content in the kidney (P < 0.001), while zinc intake decreased Cu concentration in muscle (P = 0.021). In conclusion, the simultaneous administration of organic Zn and TE positively affected the antioxidant response of kidneys and can be used for improving the antioxidant status of growing rabbits.
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spelling pubmed-85694482021-11-06 Changes in the Antioxidant and Mineral Status of Rabbits After Administration of Dietary Zinc and/or Thyme Extract Kucková, Katarína Grešáková, L'ubomíra Takácsová, Margaréta Kandričáková, Anna Chrastinová, L'ubica Polačiková, Mária Cieslak, Adam Ślusarczyk, Sylwester Čobanová, Klaudia Front Vet Sci Veterinary Science This study was aimed at determining the impact of organic zinc (Zn) and thyme extract (TE) administration, given alone or together for 6 weeks, on the antioxidant and mineral status (Zn, Cu, Fe, and Mn) in the plasma and tissues of growing rabbits. A total of 96 rabbits of age 35 days were randomly assigned to one of four treatment groups: a control group (C), a Zn group supplemented with dietary zinc (50 mg/kg), a TE group receiving thyme extract applied in drinking water (1 ml/L), and a Zn + TE group treated with both additives. Lipid peroxidation in the plasma was influenced by Zn intake and in the kidney was affected by both the Zn and TE treatment (P < 0.05). Zn supplementation led to a significant increase in glutathione peroxidase activity (P = 0.017), total antioxidant capacity (P = 0.009) and total thiol groups level (P = 0.047) in the kidney, with the highest values occurring in rabbits receiving the combination Zn + TE. Administration of TE influenced Zn content in the kidney (P < 0.001), while zinc intake decreased Cu concentration in muscle (P = 0.021). In conclusion, the simultaneous administration of organic Zn and TE positively affected the antioxidant response of kidneys and can be used for improving the antioxidant status of growing rabbits. Frontiers Media S.A. 2021-10-22 /pmc/articles/PMC8569448/ /pubmed/34746281 http://dx.doi.org/10.3389/fvets.2021.740658 Text en Copyright © 2021 Kucková, Grešáková, Takácsová, Kandričáková, Chrastinová, Polačiková, Cieslak, Ślusarczyk and Čobanová. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Kucková, Katarína
Grešáková, L'ubomíra
Takácsová, Margaréta
Kandričáková, Anna
Chrastinová, L'ubica
Polačiková, Mária
Cieslak, Adam
Ślusarczyk, Sylwester
Čobanová, Klaudia
Changes in the Antioxidant and Mineral Status of Rabbits After Administration of Dietary Zinc and/or Thyme Extract
title Changes in the Antioxidant and Mineral Status of Rabbits After Administration of Dietary Zinc and/or Thyme Extract
title_full Changes in the Antioxidant and Mineral Status of Rabbits After Administration of Dietary Zinc and/or Thyme Extract
title_fullStr Changes in the Antioxidant and Mineral Status of Rabbits After Administration of Dietary Zinc and/or Thyme Extract
title_full_unstemmed Changes in the Antioxidant and Mineral Status of Rabbits After Administration of Dietary Zinc and/or Thyme Extract
title_short Changes in the Antioxidant and Mineral Status of Rabbits After Administration of Dietary Zinc and/or Thyme Extract
title_sort changes in the antioxidant and mineral status of rabbits after administration of dietary zinc and/or thyme extract
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569448/
https://www.ncbi.nlm.nih.gov/pubmed/34746281
http://dx.doi.org/10.3389/fvets.2021.740658
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