Inhibition of nonsense-mediated decay rescues p53β/γ isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers

Inactivation of p53 is present in almost every tumor, and hence, p53-reactivation strategies are an important aspect of cancer therapy. Common mechanisms for p53 loss in cancer include expression of p53-negative regulators such as MDM2, which mediate the degradation of wildtype p53 (p53α), and inact...

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Detalles Bibliográficos
Autores principales: Gudikote, Jayanthi P., Cascone, Tina, Poteete, Alissa, Sitthideatphaiboon, Piyada, Wu, Qiuyu, Morikawa, Naoto, Zhang, Fahao, Peng, Shaohua, Tong, Pan, Li, Lerong, Shen, Li, Nilsson, Monique, Jones, Phillip, Sulman, Erik P., Wang, Jing, Bourdon, Jean-Christophe, Johnson, Faye M., Heymach, John V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569473/
https://www.ncbi.nlm.nih.gov/pubmed/34481841
http://dx.doi.org/10.1016/j.jbc.2021.101163

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