In-solution buffer-free digestion allows full-sequence coverage and complete characterization of post-translational modifications of the receptor-binding domain of SARS-CoV-2 in a single ESI–MS spectrum

Subunit vaccines based on the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 provide one of the most promising strategies to fight the COVID-19 pandemic. The detailed characterization of the protein primary structure by mass spectrometry (MS) is mandatory, as described in ICHQ6B gu...

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Detalles Bibliográficos
Autores principales: Espinosa, Luis Ariel, Ramos, Yassel, Andújar, Ivan, Torres, Enso Onill, Cabrera, Gleysin, Martín, Alejandro, Roche, Diamilé, Chinea, Glay, Becquet, Mónica, González, Isabel, Canaán-Haden, Camila, Nelson, Elías, Rojas, Gertrudis, Pérez-Massón, Beatriz, Pérez-Martínez, Dayana, Boggiano, Tamy, Palacio, Julio, Lozada Chang, Sum Lai, Hernández, Lourdes, de la Luz Hernández, Kathya Rashida, Markku, Saloheimo, Vitikainen, Marika, Valdés-Balbín, Yury, Santana-Medero, Darielys, Rivera, Daniel G., Vérez-Bencomo, Vicente, Emalfarb, Mark, Tchelet, Ronen, Guillén, Gerardo, Limonta, Miladys, Pimentel, Eulogio, Ayala, Marta, Besada, Vladimir, González, Luis Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569510/
https://www.ncbi.nlm.nih.gov/pubmed/34739558
http://dx.doi.org/10.1007/s00216-021-03721-w

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