Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice

Meiotic arrest is a common cause of human male infertility, but the causes of this arrest are poorly understood. Transactive response DNA-binding protein of 43 kDa (TDP-43) is highly expressed in spermatocytes in the preleptotene and pachytene stages of meiosis. TDP-43 is linked to several human neu...

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Detalles Bibliográficos
Autores principales: Campbell, Kaitlyn M., Xu, Yiding, Patel, Chintan, Rayl, Jeremy M., Zomer, Helena D., Osuru, Hari Prasad, Pratt, Michael, Pramoonjago, Patcharin, Timken, Madeline, Miller, Lyndzi M., Ralph, Abigail, Storey, Kathryn M., Peng, Yiheng, Drnevich, Jenny, Lagier-Tourenne, Clotilde, Wong, Philip C., Qiao, Huanyu, Reddi, Prabhakara P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569592/
https://www.ncbi.nlm.nih.gov/pubmed/34599968
http://dx.doi.org/10.1016/j.jbc.2021.101231

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