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Metabolic risk factors and fertility disorders: A narrative review of the female perspective
Metabolic risk factors such as obesity are considered major obstacles to female fertility. Chronic infertility imposes psychological and social burdens on women because infertility violates societal gender roles. Although the prevalence of obesity among women is expected to increase in the future, t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569630/ https://www.ncbi.nlm.nih.gov/pubmed/34765754 http://dx.doi.org/10.1016/j.rbms.2021.09.002 |
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author | Westerman, Ronny Kuhnt, Anne-Kristin |
author_facet | Westerman, Ronny Kuhnt, Anne-Kristin |
author_sort | Westerman, Ronny |
collection | PubMed |
description | Metabolic risk factors such as obesity are considered major obstacles to female fertility. Chronic infertility imposes psychological and social burdens on women because infertility violates societal gender roles. Although the prevalence of obesity among women is expected to increase in the future, the relevance of metabolic status for fertility is still underestimated. However, the assessment of metabolic risk factors is highly relevant for understanding fertility disorders and improving infertility treatment. This narrative review discusses the associations of metabolic risk factors (e.g. obesity, female athlete triad, oxidative stress) with significant infertility. An electronic search was conducted for studies published between 2006 and 2020 in Cumulative Index to Nursing and Allied Health Literature, ScienceDirect, PubMed, Scopus, Google Scholar and related databases. In total, this search identified 19,309 results for polycystic ovary syndrome, 28,969 results for endometriosis, and only 1611 results for idiopathic and/or unknown infertility. For the present narrative review, 50 relevant studies were included: 19 studies were on obesity, 24 studies investigated the female athlete triad, and seven studies addressed other risk factors, including reactive oxygen species. This narrative review confirms the direct impact of obesity on female infertility, while the effect of other risk factors needs to be confirmed by large-scale population studies. |
format | Online Article Text |
id | pubmed-8569630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-85696302021-11-10 Metabolic risk factors and fertility disorders: A narrative review of the female perspective Westerman, Ronny Kuhnt, Anne-Kristin Reprod Biomed Soc Online Review Metabolic risk factors such as obesity are considered major obstacles to female fertility. Chronic infertility imposes psychological and social burdens on women because infertility violates societal gender roles. Although the prevalence of obesity among women is expected to increase in the future, the relevance of metabolic status for fertility is still underestimated. However, the assessment of metabolic risk factors is highly relevant for understanding fertility disorders and improving infertility treatment. This narrative review discusses the associations of metabolic risk factors (e.g. obesity, female athlete triad, oxidative stress) with significant infertility. An electronic search was conducted for studies published between 2006 and 2020 in Cumulative Index to Nursing and Allied Health Literature, ScienceDirect, PubMed, Scopus, Google Scholar and related databases. In total, this search identified 19,309 results for polycystic ovary syndrome, 28,969 results for endometriosis, and only 1611 results for idiopathic and/or unknown infertility. For the present narrative review, 50 relevant studies were included: 19 studies were on obesity, 24 studies investigated the female athlete triad, and seven studies addressed other risk factors, including reactive oxygen species. This narrative review confirms the direct impact of obesity on female infertility, while the effect of other risk factors needs to be confirmed by large-scale population studies. Elsevier 2021-10-01 /pmc/articles/PMC8569630/ /pubmed/34765754 http://dx.doi.org/10.1016/j.rbms.2021.09.002 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Westerman, Ronny Kuhnt, Anne-Kristin Metabolic risk factors and fertility disorders: A narrative review of the female perspective |
title | Metabolic risk factors and fertility disorders: A narrative review of the female perspective |
title_full | Metabolic risk factors and fertility disorders: A narrative review of the female perspective |
title_fullStr | Metabolic risk factors and fertility disorders: A narrative review of the female perspective |
title_full_unstemmed | Metabolic risk factors and fertility disorders: A narrative review of the female perspective |
title_short | Metabolic risk factors and fertility disorders: A narrative review of the female perspective |
title_sort | metabolic risk factors and fertility disorders: a narrative review of the female perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569630/ https://www.ncbi.nlm.nih.gov/pubmed/34765754 http://dx.doi.org/10.1016/j.rbms.2021.09.002 |
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