De Novo Histoid Leprosy With Unusual Histological Features

Histoid leprosy is a type of multibacillary leprosy that has unique clinical and histological characteristics. Some consider it to be an entity of its own, whereas others view it as a variant of lepromatous leprosy. Histoid leprosy can either occur 'de-novo', or secondarily in patients who relapse after dapsone monotherapy or in the presence of dapsone resistance. Here is a case that presented with clinical features of histoid leprosy but also with classic histologic features of lepromatous leprosy, deeming it very distinctive and unusual.