New Pyrimidine and Pyridine Derivatives as Multitarget Cholinesterase Inhibitors: Design, Synthesis, and In Vitro and In Cellulo Evaluation

[Image: see text] A new series of pyrimidine and pyridine diamines was designed as dual binding site inhibitors of cholinesterases (ChEs), characterized by two small aromatic moieties separated by a diaminoalkyl flexible linker. Many compounds are mixed or uncompetitive acetylcholinesterase (AChE) a...

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Detalles Bibliográficos
Autores principales: Bortolami, Martina, Pandolfi, Fabiana, Tudino, Valeria, Messore, Antonella, Madia, Valentina Noemi, De Vita, Daniela, Di Santo, Roberto, Costi, Roberta, Romeo, Isabella, Alcaro, Stefano, Colone, Marisa, Stringaro, Annarita, Espargaró, Alba, Sabatè, Raimon, Scipione, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569681/
https://www.ncbi.nlm.nih.gov/pubmed/34652128
http://dx.doi.org/10.1021/acschemneuro.1c00485

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