Downstream processing of spray-dried ASD with hypromellose acetate succinate – Roller compaction and subsequent compression into high ASD load tablets

Despite wide commercial application of hypromellose acetate succinate (HPMCAS) in spray-dried amorphous solid dispersion (ASD) drug products, little information is available in the references on downstream processing of spray-dried dispersions with HPMCAS. Poor flow and high dilution factor are a ch...

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Detalles Bibliográficos
Autores principales: Sauer, Andreas, Warashina, Shogo, Mishra, Saurabh M, Lesser, Ilja, Kirchhöfer, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569717/
https://www.ncbi.nlm.nih.gov/pubmed/34765966
http://dx.doi.org/10.1016/j.ijpx.2021.100099

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