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Reference values for T and B lymphocyte subpopulations in Turkish children and adults

BACKGROUND/AIM: Established reference values are critical for the interpretation of immunologic assessments. In particular, the proportion and absolute counts of T- and B- cell subpopulations are subject to change with age and ethnicity. We aimed to establish age-specific reference values for lympho...

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Detalles Bibliográficos
Autores principales: BESCİ, Özge, BAŞER, Dilek, ÖĞÜLÜR, İsmail, BERBEROĞLU, Ayşe Cansu, KIYKIM, Ayça, BESCİ, Tolga, LEBLEBİCİ, Asım, ELLİDOKUZ, Hülya, BORAN, Perran, ÖZEK, Eren, HAKLAR, Goncagül, ÖZEN, Ahmet, BARIŞ, Safa, AYDINER, Elif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569764/
https://www.ncbi.nlm.nih.gov/pubmed/33754649
http://dx.doi.org/10.3906/sag-2010-176
Descripción
Sumario:BACKGROUND/AIM: Established reference values are critical for the interpretation of immunologic assessments. In particular, the proportion and absolute counts of T- and B- cell subpopulations are subject to change with age and ethnicity. We aimed to establish age-specific reference values for lymphocyte subsets using updated immunophenotyping panels. MATERIALS AND METHODS: We studied a total of 297 healthy Turkish subjects aged 0 to 50 years, stratified into major age brackets in a cluster factor of 10 per age-group. The predetermined age intervals contained randomly allocated participants enrolled over a period of 6 months, who were homogenously distributed by sex. We analyzed a complete blood count test and simultaneously with detailed immunophenotyping enumerated the percent and absolute cell counts of lymphocyte subsets. RESULTS: The percentage and absolute counts of lymphocyte subsets show a marked surge across the age-span. T helper, T cytotoxic, and the natural killer cell numbers were increasing from birth until 6 months, followed by a gradual decrease thereafter. B cell numbers were rising until 2 years, followed by a gradual decrease for the upcoming years, accompanied by a steady expansion of unclass-switched- and class-switched- B cells. CONCLUSION: We provide updated extensive reference intervals for lymphocyte subpopulations in Turkish people.