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Acute meningoencephalitis associated with SARS-CoV-2 infection in Colombia
We present the case of a patient in the third decade of life, with asthma as comorbidity, who presented to the emergency department due to odynophagia, dyspnea, and cough of 2 days of evolution, later developing acute ventilatory failure requiring orotracheal intubation. The high-resolution chest to...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569848/ https://www.ncbi.nlm.nih.gov/pubmed/34739714 http://dx.doi.org/10.1007/s13365-021-01023-6 |
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author | Palacio-Toro, María A. Hernández-Botero, Johan S. Duque-Montoya, Daniela Osorio, Yuly Echeverry, Alejandro Osorio-Maldonado, Johanna J. Orjuela-Rodríguez, Marcela Rodríguez-Morales, Alfonso J. |
author_facet | Palacio-Toro, María A. Hernández-Botero, Johan S. Duque-Montoya, Daniela Osorio, Yuly Echeverry, Alejandro Osorio-Maldonado, Johanna J. Orjuela-Rodríguez, Marcela Rodríguez-Morales, Alfonso J. |
author_sort | Palacio-Toro, María A. |
collection | PubMed |
description | We present the case of a patient in the third decade of life, with asthma as comorbidity, who presented to the emergency department due to odynophagia, dyspnea, and cough of 2 days of evolution, later developing acute ventilatory failure requiring orotracheal intubation. The high-resolution chest tomography study showed consolidation due to a pneumonic process towards the posterior segment of the right lower lobe with areas of ground-glass infiltrates with a peripheral distribution. During the clinical course, the patient presented multiple seizure episodes that met the criteria for status epilepticus with MRI compatible with changes due to leptomeningitis. Given symptoms and thorax imaging, tests for SARS-CoV-2 ensued, with both positive RT-PCR in bronchoalveolar lavage and cerebrospinal fluid for the virus also positive. RT-PCR multiplex panel of meningitis/encephalitis results negative for 14 common organisms. A diagnosis of acute meningoencephalitis associated with COVID-19 was considered, with an adequate response to corticosteroid management; to our knowledge, this is the first adult patient with CNS involvement and CSF positive test in Latin America. |
format | Online Article Text |
id | pubmed-8569848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-85698482021-11-05 Acute meningoencephalitis associated with SARS-CoV-2 infection in Colombia Palacio-Toro, María A. Hernández-Botero, Johan S. Duque-Montoya, Daniela Osorio, Yuly Echeverry, Alejandro Osorio-Maldonado, Johanna J. Orjuela-Rodríguez, Marcela Rodríguez-Morales, Alfonso J. J Neurovirol Case Report We present the case of a patient in the third decade of life, with asthma as comorbidity, who presented to the emergency department due to odynophagia, dyspnea, and cough of 2 days of evolution, later developing acute ventilatory failure requiring orotracheal intubation. The high-resolution chest tomography study showed consolidation due to a pneumonic process towards the posterior segment of the right lower lobe with areas of ground-glass infiltrates with a peripheral distribution. During the clinical course, the patient presented multiple seizure episodes that met the criteria for status epilepticus with MRI compatible with changes due to leptomeningitis. Given symptoms and thorax imaging, tests for SARS-CoV-2 ensued, with both positive RT-PCR in bronchoalveolar lavage and cerebrospinal fluid for the virus also positive. RT-PCR multiplex panel of meningitis/encephalitis results negative for 14 common organisms. A diagnosis of acute meningoencephalitis associated with COVID-19 was considered, with an adequate response to corticosteroid management; to our knowledge, this is the first adult patient with CNS involvement and CSF positive test in Latin America. Springer International Publishing 2021-11-05 2021 /pmc/articles/PMC8569848/ /pubmed/34739714 http://dx.doi.org/10.1007/s13365-021-01023-6 Text en © Journal of NeuroVirology, Inc. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Case Report Palacio-Toro, María A. Hernández-Botero, Johan S. Duque-Montoya, Daniela Osorio, Yuly Echeverry, Alejandro Osorio-Maldonado, Johanna J. Orjuela-Rodríguez, Marcela Rodríguez-Morales, Alfonso J. Acute meningoencephalitis associated with SARS-CoV-2 infection in Colombia |
title | Acute meningoencephalitis associated with SARS-CoV-2 infection in Colombia |
title_full | Acute meningoencephalitis associated with SARS-CoV-2 infection in Colombia |
title_fullStr | Acute meningoencephalitis associated with SARS-CoV-2 infection in Colombia |
title_full_unstemmed | Acute meningoencephalitis associated with SARS-CoV-2 infection in Colombia |
title_short | Acute meningoencephalitis associated with SARS-CoV-2 infection in Colombia |
title_sort | acute meningoencephalitis associated with sars-cov-2 infection in colombia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569848/ https://www.ncbi.nlm.nih.gov/pubmed/34739714 http://dx.doi.org/10.1007/s13365-021-01023-6 |
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