Molecular typing and antifungal drug susceptivity profile of Rhodotorula mucilaginosa from canine skin and ear canal

Rhodotorula mucilaginosa are saprophytic yeast, and opportunistic infections known as human rhodotorulosis are increasing in immunocompromised patients. In this study, we isolated R. mucilaginosa from pet dogs in Japan and determined the minimum inhibitory concentrations (MICs) of antifungal drugs o...

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Autores principales: SAIKA, Honami, MURAYAMA, Nobuo, KANO, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2021
Materias:
Bacteriology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569882/
https://www.ncbi.nlm.nih.gov/pubmed/34526416
http://dx.doi.org/10.1292/jvms.21-0361
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author SAIKA, Honami
MURAYAMA, Nobuo
KANO, Rui
author_facet SAIKA, Honami
MURAYAMA, Nobuo
KANO, Rui
author_sort SAIKA, Honami
collection PubMed
description Rhodotorula mucilaginosa are saprophytic yeast, and opportunistic infections known as human rhodotorulosis are increasing in immunocompromised patients. In this study, we isolated R. mucilaginosa from pet dogs in Japan and determined the minimum inhibitory concentrations (MICs) of antifungal drugs on these isolates to investigate the drug susceptibility pattern. All 10 isolates according to the broth microdilution (BM) assay of the Clinical and Laboratory Standards Institute (CLSI) M27-A2 were resistance to azoles and genetically close to fluconazole (FLZ)-resistant human isolates of R. mucilaginosa. Due to resistance, it is expected that treatment will be difficult if they infect humans.
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spelling pubmed-85698822021-11-10 Molecular typing and antifungal drug susceptivity profile of Rhodotorula mucilaginosa from canine skin and ear canal SAIKA, Honami MURAYAMA, Nobuo KANO, Rui J Vet Med Sci Bacteriology Rhodotorula mucilaginosa are saprophytic yeast, and opportunistic infections known as human rhodotorulosis are increasing in immunocompromised patients. In this study, we isolated R. mucilaginosa from pet dogs in Japan and determined the minimum inhibitory concentrations (MICs) of antifungal drugs on these isolates to investigate the drug susceptibility pattern. All 10 isolates according to the broth microdilution (BM) assay of the Clinical and Laboratory Standards Institute (CLSI) M27-A2 were resistance to azoles and genetically close to fluconazole (FLZ)-resistant human isolates of R. mucilaginosa. Due to resistance, it is expected that treatment will be difficult if they infect humans. The Japanese Society of Veterinary Science 2021-09-14 2021-10 /pmc/articles/PMC8569882/ /pubmed/34526416 http://dx.doi.org/10.1292/jvms.21-0361 Text en ©2021 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Bacteriology
SAIKA, Honami
MURAYAMA, Nobuo
KANO, Rui
Molecular typing and antifungal drug susceptivity profile of Rhodotorula mucilaginosa from canine skin and ear canal
title Molecular typing and antifungal drug susceptivity profile of Rhodotorula mucilaginosa from canine skin and ear canal
title_full Molecular typing and antifungal drug susceptivity profile of Rhodotorula mucilaginosa from canine skin and ear canal
title_fullStr Molecular typing and antifungal drug susceptivity profile of Rhodotorula mucilaginosa from canine skin and ear canal
title_full_unstemmed Molecular typing and antifungal drug susceptivity profile of Rhodotorula mucilaginosa from canine skin and ear canal
title_short Molecular typing and antifungal drug susceptivity profile of Rhodotorula mucilaginosa from canine skin and ear canal
title_sort molecular typing and antifungal drug susceptivity profile of rhodotorula mucilaginosa from canine skin and ear canal
topic Bacteriology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569882/
https://www.ncbi.nlm.nih.gov/pubmed/34526416
http://dx.doi.org/10.1292/jvms.21-0361
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