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Ventrolateral temporal lobectomy in normal dogs as a counterpart to human anterior temporal lobectomy: a preliminary study on the surgical procedure and complications

Anterior temporal lobectomy (ATL) is a surgical procedure for drug-resistant mesial temporal lobe epilepsy that is commonly performed in human medicine. The purpose of this study was to determine whether ATL-like surgery, i.e., removal of the amygdala and hippocampal head, is possible in dogs, and t...

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Autores principales: ASADA, Rikako, HAMAMOTO, Yuji, YU, Yoshihiko, MIZUNO, Satoshi, CHAMBERS, James K., UCHIDA, Kazuyuki, HASEGAWA, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569885/
https://www.ncbi.nlm.nih.gov/pubmed/34408102
http://dx.doi.org/10.1292/jvms.21-0127
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author ASADA, Rikako
HAMAMOTO, Yuji
YU, Yoshihiko
MIZUNO, Satoshi
CHAMBERS, James K.
UCHIDA, Kazuyuki
HASEGAWA, Daisuke
author_facet ASADA, Rikako
HAMAMOTO, Yuji
YU, Yoshihiko
MIZUNO, Satoshi
CHAMBERS, James K.
UCHIDA, Kazuyuki
HASEGAWA, Daisuke
author_sort ASADA, Rikako
collection PubMed
description Anterior temporal lobectomy (ATL) is a surgical procedure for drug-resistant mesial temporal lobe epilepsy that is commonly performed in human medicine. The purpose of this study was to determine whether ATL-like surgery, i.e., removal of the amygdala and hippocampal head, is possible in dogs, and to investigate its safety and postoperative complications. Eight healthy beagles underwent ATL-like surgery and were observed for 3 months postoperatively. Samples from the surgically resected tissues and postmortem brain were evaluated pathologically. The surgical survival rate was 62.5%. The major postoperative complications were visual impairment, temporal muscle atrophy on the operative side, and a postoperative acute symptomatic seizure. Due to the anatomical differences between dogs and humans, the surgically resected area to approach the medial temporal structures in dogs was the ventrolateral part of the temporal lobe. Therefore, the ATL-like surgery described in this study was named “ventrolateral temporal lobectomy” (VTL). This study is the first report of temporal lobectomy including amygdalohippocampectomy in veterinary medicine and demonstrates its feasibility. Although it requires some degree of skill, VTL could be a treatment option for canine drug-resistant epilepsy and lesions in the mesial temporal lobe.
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spelling pubmed-85698852021-11-10 Ventrolateral temporal lobectomy in normal dogs as a counterpart to human anterior temporal lobectomy: a preliminary study on the surgical procedure and complications ASADA, Rikako HAMAMOTO, Yuji YU, Yoshihiko MIZUNO, Satoshi CHAMBERS, James K. UCHIDA, Kazuyuki HASEGAWA, Daisuke J Vet Med Sci Surgery Anterior temporal lobectomy (ATL) is a surgical procedure for drug-resistant mesial temporal lobe epilepsy that is commonly performed in human medicine. The purpose of this study was to determine whether ATL-like surgery, i.e., removal of the amygdala and hippocampal head, is possible in dogs, and to investigate its safety and postoperative complications. Eight healthy beagles underwent ATL-like surgery and were observed for 3 months postoperatively. Samples from the surgically resected tissues and postmortem brain were evaluated pathologically. The surgical survival rate was 62.5%. The major postoperative complications were visual impairment, temporal muscle atrophy on the operative side, and a postoperative acute symptomatic seizure. Due to the anatomical differences between dogs and humans, the surgically resected area to approach the medial temporal structures in dogs was the ventrolateral part of the temporal lobe. Therefore, the ATL-like surgery described in this study was named “ventrolateral temporal lobectomy” (VTL). This study is the first report of temporal lobectomy including amygdalohippocampectomy in veterinary medicine and demonstrates its feasibility. Although it requires some degree of skill, VTL could be a treatment option for canine drug-resistant epilepsy and lesions in the mesial temporal lobe. The Japanese Society of Veterinary Science 2021-08-18 2021-10 /pmc/articles/PMC8569885/ /pubmed/34408102 http://dx.doi.org/10.1292/jvms.21-0127 Text en ©2021 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Surgery
ASADA, Rikako
HAMAMOTO, Yuji
YU, Yoshihiko
MIZUNO, Satoshi
CHAMBERS, James K.
UCHIDA, Kazuyuki
HASEGAWA, Daisuke
Ventrolateral temporal lobectomy in normal dogs as a counterpart to human anterior temporal lobectomy: a preliminary study on the surgical procedure and complications
title Ventrolateral temporal lobectomy in normal dogs as a counterpart to human anterior temporal lobectomy: a preliminary study on the surgical procedure and complications
title_full Ventrolateral temporal lobectomy in normal dogs as a counterpart to human anterior temporal lobectomy: a preliminary study on the surgical procedure and complications
title_fullStr Ventrolateral temporal lobectomy in normal dogs as a counterpart to human anterior temporal lobectomy: a preliminary study on the surgical procedure and complications
title_full_unstemmed Ventrolateral temporal lobectomy in normal dogs as a counterpart to human anterior temporal lobectomy: a preliminary study on the surgical procedure and complications
title_short Ventrolateral temporal lobectomy in normal dogs as a counterpart to human anterior temporal lobectomy: a preliminary study on the surgical procedure and complications
title_sort ventrolateral temporal lobectomy in normal dogs as a counterpart to human anterior temporal lobectomy: a preliminary study on the surgical procedure and complications
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569885/
https://www.ncbi.nlm.nih.gov/pubmed/34408102
http://dx.doi.org/10.1292/jvms.21-0127
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