Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance

Increasing evidence indicates that the tumor microenvironment appears to play an increasingly important role in cancer progression and therapeutic resistance. Several types of cells within the tumor stroma had distinct impacts on cancer progression, either promoting or inhibiting cancer cell growth....

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Autores principales: Xuan, Xiuyun, Tian, Chunxia, Zhao, Mengjie, Sun, Yanhong, Huang, Changzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570012/
https://www.ncbi.nlm.nih.gov/pubmed/34736460
http://dx.doi.org/10.1186/s12935-021-02300-4
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author Xuan, Xiuyun
Tian, Chunxia
Zhao, Mengjie
Sun, Yanhong
Huang, Changzheng
author_facet Xuan, Xiuyun
Tian, Chunxia
Zhao, Mengjie
Sun, Yanhong
Huang, Changzheng
author_sort Xuan, Xiuyun
collection PubMed
description Increasing evidence indicates that the tumor microenvironment appears to play an increasingly important role in cancer progression and therapeutic resistance. Several types of cells within the tumor stroma had distinct impacts on cancer progression, either promoting or inhibiting cancer cell growth. Mesenchymal stem cells (MSCs) are a distinct type of cells that is linked to tumor development. MSCs are recognized for homing to tumor locations and promoting or inhibiting cancer cell proliferation, angiogenesis and metastasis. Moreover, emerging studies suggests that MSCs are also involved in therapeutic resistance. In this review, we analyzed the existing researches and elaborate on the functions of MSCs in cancer progression and anticancer therapeutic resistance, demonstrating that MSCs may be a viable cancer therapeutic target.
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spelling pubmed-85700122021-11-08 Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance Xuan, Xiuyun Tian, Chunxia Zhao, Mengjie Sun, Yanhong Huang, Changzheng Cancer Cell Int Review Increasing evidence indicates that the tumor microenvironment appears to play an increasingly important role in cancer progression and therapeutic resistance. Several types of cells within the tumor stroma had distinct impacts on cancer progression, either promoting or inhibiting cancer cell growth. Mesenchymal stem cells (MSCs) are a distinct type of cells that is linked to tumor development. MSCs are recognized for homing to tumor locations and promoting or inhibiting cancer cell proliferation, angiogenesis and metastasis. Moreover, emerging studies suggests that MSCs are also involved in therapeutic resistance. In this review, we analyzed the existing researches and elaborate on the functions of MSCs in cancer progression and anticancer therapeutic resistance, demonstrating that MSCs may be a viable cancer therapeutic target. BioMed Central 2021-11-04 /pmc/articles/PMC8570012/ /pubmed/34736460 http://dx.doi.org/10.1186/s12935-021-02300-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Xuan, Xiuyun
Tian, Chunxia
Zhao, Mengjie
Sun, Yanhong
Huang, Changzheng
Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
title Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
title_full Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
title_fullStr Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
title_full_unstemmed Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
title_short Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
title_sort mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570012/
https://www.ncbi.nlm.nih.gov/pubmed/34736460
http://dx.doi.org/10.1186/s12935-021-02300-4
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