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Rapid Sequential Implication of the Human Medial Temporal Lobe in Memory Encoding and Recognition

The medial temporal lobe (MTL) is crucial for memory encoding and recognition. The time course of these processes is unknown. The present study juxtaposed encoding and recognition in a single paradigm. Twenty healthy subjects performed a continuous recognition task as brain activity was monitored wi...

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Autores principales: Tautvydaitė, Domilė, Adam-Darqué, Alexandra, Manuel, Aurélie L., Ptak, Radek, Schnider, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570128/
https://www.ncbi.nlm.nih.gov/pubmed/34744649
http://dx.doi.org/10.3389/fnbeh.2021.684647
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author Tautvydaitė, Domilė
Adam-Darqué, Alexandra
Manuel, Aurélie L.
Ptak, Radek
Schnider, Armin
author_facet Tautvydaitė, Domilė
Adam-Darqué, Alexandra
Manuel, Aurélie L.
Ptak, Radek
Schnider, Armin
author_sort Tautvydaitė, Domilė
collection PubMed
description The medial temporal lobe (MTL) is crucial for memory encoding and recognition. The time course of these processes is unknown. The present study juxtaposed encoding and recognition in a single paradigm. Twenty healthy subjects performed a continuous recognition task as brain activity was monitored with a high-density electroencephalography. The task presented New pictures thought to evoke encoding. The stimuli were then repeated up to 4 consecutive times to produce over-familiarity. These repeated stimuli served as “baseline” for comparison with the other stimuli. Stimuli later reappeared after 9–15 intervening items, presumably associated with new encoding and recognition. Encoding-related differences in evoked response potential amplitudes and in spatiotemporal analysis were observed at 145–300 ms, whereby source estimation indicated MTL and orbitofrontal activity from 145 to 205 ms. Recognition-related activity evoked by late repetitions occurred at 405–470 ms, implicating the MTL and neocortical structures. These findings indicate that encoding of information is initiated before it is recognized. The result helps to explain modifications of memories over time, including false memories, confabulation, and consolidation.
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spelling pubmed-85701282021-11-06 Rapid Sequential Implication of the Human Medial Temporal Lobe in Memory Encoding and Recognition Tautvydaitė, Domilė Adam-Darqué, Alexandra Manuel, Aurélie L. Ptak, Radek Schnider, Armin Front Behav Neurosci Neuroscience The medial temporal lobe (MTL) is crucial for memory encoding and recognition. The time course of these processes is unknown. The present study juxtaposed encoding and recognition in a single paradigm. Twenty healthy subjects performed a continuous recognition task as brain activity was monitored with a high-density electroencephalography. The task presented New pictures thought to evoke encoding. The stimuli were then repeated up to 4 consecutive times to produce over-familiarity. These repeated stimuli served as “baseline” for comparison with the other stimuli. Stimuli later reappeared after 9–15 intervening items, presumably associated with new encoding and recognition. Encoding-related differences in evoked response potential amplitudes and in spatiotemporal analysis were observed at 145–300 ms, whereby source estimation indicated MTL and orbitofrontal activity from 145 to 205 ms. Recognition-related activity evoked by late repetitions occurred at 405–470 ms, implicating the MTL and neocortical structures. These findings indicate that encoding of information is initiated before it is recognized. The result helps to explain modifications of memories over time, including false memories, confabulation, and consolidation. Frontiers Media S.A. 2021-10-22 /pmc/articles/PMC8570128/ /pubmed/34744649 http://dx.doi.org/10.3389/fnbeh.2021.684647 Text en Copyright © 2021 Tautvydaitė, Adam-Darqué, Manuel, Ptak and Schnider. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tautvydaitė, Domilė
Adam-Darqué, Alexandra
Manuel, Aurélie L.
Ptak, Radek
Schnider, Armin
Rapid Sequential Implication of the Human Medial Temporal Lobe in Memory Encoding and Recognition
title Rapid Sequential Implication of the Human Medial Temporal Lobe in Memory Encoding and Recognition
title_full Rapid Sequential Implication of the Human Medial Temporal Lobe in Memory Encoding and Recognition
title_fullStr Rapid Sequential Implication of the Human Medial Temporal Lobe in Memory Encoding and Recognition
title_full_unstemmed Rapid Sequential Implication of the Human Medial Temporal Lobe in Memory Encoding and Recognition
title_short Rapid Sequential Implication of the Human Medial Temporal Lobe in Memory Encoding and Recognition
title_sort rapid sequential implication of the human medial temporal lobe in memory encoding and recognition
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570128/
https://www.ncbi.nlm.nih.gov/pubmed/34744649
http://dx.doi.org/10.3389/fnbeh.2021.684647
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