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CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1

The ESCRT protein CHMP2B and the RNA-binding protein TDP-43 are both associated with ALS and FTD. The pathogenicity of CHMP2B has mainly been considered a consequence of autophagy–endolysosomal dysfunction, whereas protein inclusions containing phosphorylated TDP-43 are a pathological hallmark of AL...

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Detalles Bibliográficos
Autores principales:	Deng, Xue, Sun, Xing, Yue, Wenkai, Duan, Yongjia, Hu, Rirong, Zhang, Kai, Ni, Jiangxia, Cui, Jihong, Wang, Qiangqiang, Chen, Yelin, Li, Ang, Fang, Yanshan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570292/ https://www.ncbi.nlm.nih.gov/pubmed/34726688 http://dx.doi.org/10.1083/jcb.202103033

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