Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci

Chromatin accessibility and gene expression in relevant cell contexts can guide identification of regulatory elements and mechanisms at genome-wide association study (GWAS) loci. To identify regulatory elements that display differential activity across adipocyte differentiation, we performed ATAC-se...

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Detalles Bibliográficos
Autores principales: Perrin, Hannah J., Currin, Kevin W., Vadlamudi, Swarooparani, Pandey, Gautam K., Ng, Kenneth K., Wabitsch, Martin, Laakso, Markku, Love, Michael I., Mohlke, Karen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570510/
https://www.ncbi.nlm.nih.gov/pubmed/34699533
http://dx.doi.org/10.1371/journal.pgen.1009865

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