DNA methylation at a nutritionally sensitive region of the PAX8 gene is associated with thyroid volume and function in Gambian children

PAX8 is a key thyroid transcription factor implicated in thyroid gland differentiation and function, and PAX8 gene methylation is reported to be sensitive to the periconceptional environment. Using a novel recall-by-epigenotype study in Gambian children, we found that PAX8 hypomethylation at age 2 y...

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Detalles Bibliográficos
Autores principales: Candler, Toby, Kessler, Noah, Gunasekara, Chathura, Ward, Kate, James, Philip, Laritsky, Eleonora, Baker, Maria, Dyer, Roger, Elango, Rajavel, Jeffries, David, Waterland, Robert, Moore, Sophie, Ludgate, Marian, Prentice, Andrew, Silver, Matt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570597/
https://www.ncbi.nlm.nih.gov/pubmed/34739318
http://dx.doi.org/10.1126/sciadv.abj1561

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