The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases

Selected patients with brain metastases (BM) are candidates for radiotherapy. A lactatogenic metabolism, common in BM, has been associated with radioresistance. We demonstrated that BM express nitric oxide (NO) synthase 2 and that administration of its substrate l-arginine decreases tumor lactate in...

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Detalles Bibliográficos
Autores principales: Marullo, Rossella, Castro, Monica, Yomtoubian, Shira, Calvo-Vidal, M. Nieves, Revuelta, Maria Victoria, Krumsiek, Jan, Cho, Andrew, Morgado, Pablo Cresta, Yang, ShaoNing, Medina, Vanina, Roth, Berta M., Bonomi, Marcelo, Keshari, Kayvan R., Mittal, Vivek, Navigante, Alfredo, Cerchietti, Leandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570607/
https://www.ncbi.nlm.nih.gov/pubmed/34739311
http://dx.doi.org/10.1126/sciadv.abg1964

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