Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD

Sequential mannose trimming of N-glycan, from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). We previously showed that EDEM2 stably disulfide-bonded to t...

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Detalles Bibliográficos
Autores principales: George, Ginto, Ninagawa, Satoshi, Yagi, Hirokazu, Furukawa, Jun-ichi, Hashii, Noritaka, Ishii-Watabe, Akiko, Deng, Ying, Matsushita, Kazutoshi, Ishikawa, Tokiro, Mamahit, Yugoviandi P, Maki, Yuta, Kajihara, Yasuhiro, Kato, Koichi, Okada, Tetsuya, Mori, Kazutoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570694/
https://www.ncbi.nlm.nih.gov/pubmed/34698634
http://dx.doi.org/10.7554/eLife.70357

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