Cargando…

From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum

Structural and functional integrity of the cerebral vasculature ensures proper brain development and function, as well as healthy aging. The inability of the brain to store energy makes it exceptionally dependent on an adequate supply of oxygen and nutrients from the blood stream for matching coloss...

Descripción completa

Detalles Bibliográficos
Autores principales: Ouellette, Julie, Lacoste, Baptiste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570842/
https://www.ncbi.nlm.nih.gov/pubmed/34744690
http://dx.doi.org/10.3389/fnagi.2021.749026
_version_ 1784594900256292864
author Ouellette, Julie
Lacoste, Baptiste
author_facet Ouellette, Julie
Lacoste, Baptiste
author_sort Ouellette, Julie
collection PubMed
description Structural and functional integrity of the cerebral vasculature ensures proper brain development and function, as well as healthy aging. The inability of the brain to store energy makes it exceptionally dependent on an adequate supply of oxygen and nutrients from the blood stream for matching colossal demands of neural and glial cells. Key vascular features including a dense vasculature, a tightly controlled environment, and the regulation of cerebral blood flow (CBF) all take part in brain health throughout life. As such, healthy brain development and aging are both ensured by the anatomical and functional interaction between the vascular and nervous systems that are established during brain development and maintained throughout the lifespan. During critical periods of brain development, vascular networks remodel until they can actively respond to increases in neural activity through neurovascular coupling, which makes the brain particularly vulnerable to neurovascular alterations. The brain vasculature has been strongly associated with the onset and/or progression of conditions associated with aging, and more recently with neurodevelopmental disorders. Our understanding of cerebrovascular contributions to neurological disorders is rapidly evolving, and increasing evidence shows that deficits in angiogenesis, CBF and the blood-brain barrier (BBB) are causally linked to cognitive impairment. Moreover, it is of utmost curiosity that although neurodevelopmental and neurodegenerative disorders express different clinical features at different stages of life, they share similar vascular abnormalities. In this review, we present an overview of vascular dysfunctions associated with neurodevelopmental (autism spectrum disorders, schizophrenia, Down Syndrome) and neurodegenerative (multiple sclerosis, Huntington’s, Parkinson’s, and Alzheimer’s diseases) disorders, with a focus on impairments in angiogenesis, CBF and the BBB. Finally, we discuss the impact of early vascular impairments on the expression of neurodegenerative diseases.
format Online
Article
Text
id pubmed-8570842
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85708422021-11-06 From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum Ouellette, Julie Lacoste, Baptiste Front Aging Neurosci Neuroscience Structural and functional integrity of the cerebral vasculature ensures proper brain development and function, as well as healthy aging. The inability of the brain to store energy makes it exceptionally dependent on an adequate supply of oxygen and nutrients from the blood stream for matching colossal demands of neural and glial cells. Key vascular features including a dense vasculature, a tightly controlled environment, and the regulation of cerebral blood flow (CBF) all take part in brain health throughout life. As such, healthy brain development and aging are both ensured by the anatomical and functional interaction between the vascular and nervous systems that are established during brain development and maintained throughout the lifespan. During critical periods of brain development, vascular networks remodel until they can actively respond to increases in neural activity through neurovascular coupling, which makes the brain particularly vulnerable to neurovascular alterations. The brain vasculature has been strongly associated with the onset and/or progression of conditions associated with aging, and more recently with neurodevelopmental disorders. Our understanding of cerebrovascular contributions to neurological disorders is rapidly evolving, and increasing evidence shows that deficits in angiogenesis, CBF and the blood-brain barrier (BBB) are causally linked to cognitive impairment. Moreover, it is of utmost curiosity that although neurodevelopmental and neurodegenerative disorders express different clinical features at different stages of life, they share similar vascular abnormalities. In this review, we present an overview of vascular dysfunctions associated with neurodevelopmental (autism spectrum disorders, schizophrenia, Down Syndrome) and neurodegenerative (multiple sclerosis, Huntington’s, Parkinson’s, and Alzheimer’s diseases) disorders, with a focus on impairments in angiogenesis, CBF and the BBB. Finally, we discuss the impact of early vascular impairments on the expression of neurodegenerative diseases. Frontiers Media S.A. 2021-10-20 /pmc/articles/PMC8570842/ /pubmed/34744690 http://dx.doi.org/10.3389/fnagi.2021.749026 Text en Copyright © 2021 Ouellette and Lacoste. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ouellette, Julie
Lacoste, Baptiste
From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum
title From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum
title_full From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum
title_fullStr From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum
title_full_unstemmed From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum
title_short From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum
title_sort from neurodevelopmental to neurodegenerative disorders: the vascular continuum
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570842/
https://www.ncbi.nlm.nih.gov/pubmed/34744690
http://dx.doi.org/10.3389/fnagi.2021.749026
work_keys_str_mv AT ouellettejulie fromneurodevelopmentaltoneurodegenerativedisordersthevascularcontinuum
AT lacostebaptiste fromneurodevelopmentaltoneurodegenerativedisordersthevascularcontinuum