Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management

Type 2 diabetes is one of the most relevant risk factors for heart failure, the prevalence of which is increasing worldwide. The aim of the review is to highlight the current perspectives of the pathophysiology of heart failure as it pertains to type 2 diabetes. This review summarizes the proposed m...

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Autores principales: Ceriello, Antonio, Catrinoiu, Doina, Chandramouli, Chanchal, Cosentino, Francesco, Dombrowsky, Annique Cornelia, Itzhak, Baruch, Lalic, Nebojsa Malić, Prattichizzo, Francesco, Schnell, Oliver, Seferović, Petar M., Valensi, Paul, Standl, Eberhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571004/
https://www.ncbi.nlm.nih.gov/pubmed/34740359
http://dx.doi.org/10.1186/s12933-021-01408-1
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author Ceriello, Antonio
Catrinoiu, Doina
Chandramouli, Chanchal
Cosentino, Francesco
Dombrowsky, Annique Cornelia
Itzhak, Baruch
Lalic, Nebojsa Malić
Prattichizzo, Francesco
Schnell, Oliver
Seferović, Petar M.
Valensi, Paul
Standl, Eberhard
author_facet Ceriello, Antonio
Catrinoiu, Doina
Chandramouli, Chanchal
Cosentino, Francesco
Dombrowsky, Annique Cornelia
Itzhak, Baruch
Lalic, Nebojsa Malić
Prattichizzo, Francesco
Schnell, Oliver
Seferović, Petar M.
Valensi, Paul
Standl, Eberhard
author_sort Ceriello, Antonio
collection PubMed
description Type 2 diabetes is one of the most relevant risk factors for heart failure, the prevalence of which is increasing worldwide. The aim of the review is to highlight the current perspectives of the pathophysiology of heart failure as it pertains to type 2 diabetes. This review summarizes the proposed mechanistic bases, explaining the myocardial damage induced by diabetes-related stressors and other risk factors, i.e., cardiomyopathy in type 2 diabetes. We highlight the complex pathology of individuals with type 2 diabetes, including the relationship with chronic kidney disease, metabolic alterations, and heart failure. We also discuss the current criteria used for heart failure diagnosis and the gold standard screening tools for individuals with type 2 diabetes. Currently approved pharmacological therapies with primary use in type 2 diabetes and heart failure, and the treatment-guiding role of NT-proBNP are also presented. Finally, the influence of the presence of type 2 diabetes as well as heart failure on COVID-19 severity is briefly discussed.
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spelling pubmed-85710042021-11-08 Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management Ceriello, Antonio Catrinoiu, Doina Chandramouli, Chanchal Cosentino, Francesco Dombrowsky, Annique Cornelia Itzhak, Baruch Lalic, Nebojsa Malić Prattichizzo, Francesco Schnell, Oliver Seferović, Petar M. Valensi, Paul Standl, Eberhard Cardiovasc Diabetol Review Type 2 diabetes is one of the most relevant risk factors for heart failure, the prevalence of which is increasing worldwide. The aim of the review is to highlight the current perspectives of the pathophysiology of heart failure as it pertains to type 2 diabetes. This review summarizes the proposed mechanistic bases, explaining the myocardial damage induced by diabetes-related stressors and other risk factors, i.e., cardiomyopathy in type 2 diabetes. We highlight the complex pathology of individuals with type 2 diabetes, including the relationship with chronic kidney disease, metabolic alterations, and heart failure. We also discuss the current criteria used for heart failure diagnosis and the gold standard screening tools for individuals with type 2 diabetes. Currently approved pharmacological therapies with primary use in type 2 diabetes and heart failure, and the treatment-guiding role of NT-proBNP are also presented. Finally, the influence of the presence of type 2 diabetes as well as heart failure on COVID-19 severity is briefly discussed. BioMed Central 2021-11-06 /pmc/articles/PMC8571004/ /pubmed/34740359 http://dx.doi.org/10.1186/s12933-021-01408-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ceriello, Antonio
Catrinoiu, Doina
Chandramouli, Chanchal
Cosentino, Francesco
Dombrowsky, Annique Cornelia
Itzhak, Baruch
Lalic, Nebojsa Malić
Prattichizzo, Francesco
Schnell, Oliver
Seferović, Petar M.
Valensi, Paul
Standl, Eberhard
Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management
title Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management
title_full Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management
title_fullStr Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management
title_full_unstemmed Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management
title_short Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management
title_sort heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571004/
https://www.ncbi.nlm.nih.gov/pubmed/34740359
http://dx.doi.org/10.1186/s12933-021-01408-1
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