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Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction

Interleukin (IL)-12 and IL-23 are composite cytokines consisting of p35/p40 and p19/p40, respectively, which signal via the common IL-12 receptor β1 (IL-12Rβ1) and the cytokine-specific receptors IL-12Rβ2 and IL-23R. Previous data showed that the p40 component interacts with IL-12Rβ1, whereas p19 an...

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Detalles Bibliográficos
Autores principales:	Georgy, Jacqueline, Arlt, Yvonne, Moll, Jens M., Ouzin, Meryem, Weitz, Hendrik T., Gremer, Lothar, Willbold, Dieter, Grötzinger, Joachim, Thives-Kurenbach, Felix, Scheller, Jürgen, Floss, Doreen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571081/ https://www.ncbi.nlm.nih.gov/pubmed/34637790 http://dx.doi.org/10.1016/j.jbc.2021.101295

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