Lamin A/C recruits ssDNA protective proteins RPA and RAD51 to stalled replication forks to maintain fork stability

Lamin A/C provides a nuclear scaffold for compartmentalization of genome function that is important for genome integrity. Lamin A/C dysfunction is associated with cancer, aging, and degenerative diseases. The mechanisms whereby lamin A/C regulates genome stability remain poorly understood. We demons...

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Detalles Bibliográficos
Autores principales: Graziano, Simona, Coll-Bonfill, Nuria, Teodoro-Castro, Barbara, Kuppa, Sahiti, Jackson, Jessica, Shashkova, Elena, Mahajan, Urvashi, Vindigni, Alessandro, Antony, Edwin, Gonzalo, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571089/
https://www.ncbi.nlm.nih.gov/pubmed/34648766
http://dx.doi.org/10.1016/j.jbc.2021.101301

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