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Co-opting regulation bypass repair as a gene-correction strategy for monogenic diseases
With the development of CRISPR-Cas9-mediated gene-editing technologies, correction of disease-causing mutations has become possible. However, current gene-correction strategies preclude mutation repair in post-mitotic cells of human tissues, and a unique repair strategy must be designed and tested f...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571108/ https://www.ncbi.nlm.nih.gov/pubmed/33892188 http://dx.doi.org/10.1016/j.ymthe.2021.04.017 |