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Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs

Nucleoside-modified messenger RNA (mRNA)-lipid nanoparticles (LNPs) are the basis for the first two EUA (Emergency Use Authorization) COVID-19 vaccines. The use of nucleoside-modified mRNA as a pharmacological agent opens immense opportunities for therapeutic, prophylactic and diagnostic molecular i...

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Detalles Bibliográficos
Autores principales:	Tombácz, István, Laczkó, Dorottya, Shahnawaz, Hamna, Muramatsu, Hiromi, Natesan, Ambika, Yadegari, Amir, Papp, Tyler E., Alameh, Mohamad-Gabriel, Shuvaev, Vladimir, Mui, Barbara L., Tam, Ying K., Muzykantov, Vladimir, Pardi, Norbert, Weissman, Drew, Parhiz, Hamideh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571164/ https://www.ncbi.nlm.nih.gov/pubmed/34091054 http://dx.doi.org/10.1016/j.ymthe.2021.06.004

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