Epinephrine levels decrease in responders after electroconvulsive therapy

We examined potential changes in catecholamine plasma levels and cortisol serum levels in 29 patients with treatment-resistant Major Depressive Disorder (MDD) during a course of electroconvulsive therapy (ECT). Blood samples were taken at three different time points: directly before (T1) and 15 min...

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Detalles Bibliográficos
Autores principales: Pollak, Christoph, Maier, Hannah Benedictine, Moschny, Nicole, Jahn, Kirsten, Bleich, Stefan, Frieling, Helge, Neyazi, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Psychiatry and Preclinical Psychiatric Studies - Short communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571228/
https://www.ncbi.nlm.nih.gov/pubmed/34554316
http://dx.doi.org/10.1007/s00702-021-02420-1
Descripción
Sumario:We examined potential changes in catecholamine plasma levels and cortisol serum levels in 29 patients with treatment-resistant Major Depressive Disorder (MDD) during a course of electroconvulsive therapy (ECT). Blood samples were taken at three different time points: directly before (T1) and 15 min after (T2) the first ECT, and directly before the last one (T3). Patients responding to ECT had a significant decrease of the intraindividual epinephrine plasma level when both first time points (Δ T1-T2) were compared (χ(2) (1) = 10.05, p = 0.002). This finding encourages further investigation in the understanding of the catecholamine-metabolism including its release and uptake in patients with treatment-resistant MDD receiving ECT. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00702-021-02420-1.

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