Epinephrine levels decrease in responders after electroconvulsive therapy

We examined potential changes in catecholamine plasma levels and cortisol serum levels in 29 patients with treatment-resistant Major Depressive Disorder (MDD) during a course of electroconvulsive therapy (ECT). Blood samples were taken at three different time points: directly before (T1) and 15 min...

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Autores principales: Pollak, Christoph, Maier, Hannah Benedictine, Moschny, Nicole, Jahn, Kirsten, Bleich, Stefan, Frieling, Helge, Neyazi, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Psychiatry and Preclinical Psychiatric Studies - Short communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571228/
https://www.ncbi.nlm.nih.gov/pubmed/34554316
http://dx.doi.org/10.1007/s00702-021-02420-1
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author Pollak, Christoph
Maier, Hannah Benedictine
Moschny, Nicole
Jahn, Kirsten
Bleich, Stefan
Frieling, Helge
Neyazi, Alexandra
author_facet Pollak, Christoph
Maier, Hannah Benedictine
Moschny, Nicole
Jahn, Kirsten
Bleich, Stefan
Frieling, Helge
Neyazi, Alexandra
author_sort Pollak, Christoph
collection PubMed
description We examined potential changes in catecholamine plasma levels and cortisol serum levels in 29 patients with treatment-resistant Major Depressive Disorder (MDD) during a course of electroconvulsive therapy (ECT). Blood samples were taken at three different time points: directly before (T1) and 15 min after (T2) the first ECT, and directly before the last one (T3). Patients responding to ECT had a significant decrease of the intraindividual epinephrine plasma level when both first time points (Δ T1-T2) were compared (χ(2) (1) = 10.05, p = 0.002). This finding encourages further investigation in the understanding of the catecholamine-metabolism including its release and uptake in patients with treatment-resistant MDD receiving ECT. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00702-021-02420-1.
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spelling pubmed-85712282021-11-08 Epinephrine levels decrease in responders after electroconvulsive therapy Pollak, Christoph Maier, Hannah Benedictine Moschny, Nicole Jahn, Kirsten Bleich, Stefan Frieling, Helge Neyazi, Alexandra J Neural Transm (Vienna) Psychiatry and Preclinical Psychiatric Studies - Short communication We examined potential changes in catecholamine plasma levels and cortisol serum levels in 29 patients with treatment-resistant Major Depressive Disorder (MDD) during a course of electroconvulsive therapy (ECT). Blood samples were taken at three different time points: directly before (T1) and 15 min after (T2) the first ECT, and directly before the last one (T3). Patients responding to ECT had a significant decrease of the intraindividual epinephrine plasma level when both first time points (Δ T1-T2) were compared (χ(2) (1) = 10.05, p = 0.002). This finding encourages further investigation in the understanding of the catecholamine-metabolism including its release and uptake in patients with treatment-resistant MDD receiving ECT. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00702-021-02420-1. Springer Vienna 2021-09-23 2021 /pmc/articles/PMC8571228/ /pubmed/34554316 http://dx.doi.org/10.1007/s00702-021-02420-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Psychiatry and Preclinical Psychiatric Studies - Short communication
Pollak, Christoph
Maier, Hannah Benedictine
Moschny, Nicole
Jahn, Kirsten
Bleich, Stefan
Frieling, Helge
Neyazi, Alexandra
Epinephrine levels decrease in responders after electroconvulsive therapy
title Epinephrine levels decrease in responders after electroconvulsive therapy
title_full Epinephrine levels decrease in responders after electroconvulsive therapy
title_fullStr Epinephrine levels decrease in responders after electroconvulsive therapy
title_full_unstemmed Epinephrine levels decrease in responders after electroconvulsive therapy
title_short Epinephrine levels decrease in responders after electroconvulsive therapy
title_sort epinephrine levels decrease in responders after electroconvulsive therapy
topic Psychiatry and Preclinical Psychiatric Studies - Short communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571228/
https://www.ncbi.nlm.nih.gov/pubmed/34554316
http://dx.doi.org/10.1007/s00702-021-02420-1
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