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Abnormal Findings on “T1WI or DWI or MRCP:” An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group

OBJECTIVES: The objectives of the study was to evaluate the diagnostic performance of findings on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and magnetic resonance cholangiopancreatography (MRCP) separately and to identify an optimal Boolean interpretat...

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Autores principales: Ren, Hainan, Mori, Naoko, Hirasawa, Minami, Hamada, Shin, Mugikura, Shunji, Masamune, Atsushi, Takase, Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571256/
https://www.ncbi.nlm.nih.gov/pubmed/34754594
http://dx.doi.org/10.25259/JCIS_158_2021
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author Ren, Hainan
Mori, Naoko
Hirasawa, Minami
Hamada, Shin
Mugikura, Shunji
Masamune, Atsushi
Takase, Kei
author_facet Ren, Hainan
Mori, Naoko
Hirasawa, Minami
Hamada, Shin
Mugikura, Shunji
Masamune, Atsushi
Takase, Kei
author_sort Ren, Hainan
collection PubMed
description OBJECTIVES: The objectives of the study was to evaluate the diagnostic performance of findings on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and magnetic resonance cholangiopancreatography (MRCP) separately and to identify an optimal Boolean interpretation model for discriminating patients with small pancreatic ductal adenocarcinoma (PDAC) from control groups in clinical practice. MATERIAL AND METHODS: We retrospectively enrolled 30 patients with surgery confirmed small PDAC (≤20 mm) and 302 patients without pancreatic abnormality between April 2008 and February 2020. The presence of masses was evaluated by T1WI, T2WI, and DWI. Abnormality of the main pancreatic duct (MPD) was evaluated by T2WI and MRCP. Multivariate logistic regression analysis was performed to select significant sequences for discriminating the small PDAC and control groups. Boolean operators “OR” or “AND” were used to construct sequence combinations. Diagnostic performances of these sequences and combinations were evaluated by X(2) tests. RESULTS: The sensitivity of T2WI was lowest (20%) for detecting masses. For evaluating MPD abnormality, sensitivity was higher for MRCP than for T2WI (86.7% vs. 53.3%). Multivariate logistic regression analysis showed that T1WI and DWI for detecting the presence of masses and MRCP for evaluating MPD abnormality were significantly associated with differentiation between the two groups (P = 0.0002, P = 0.0484, and P < 0.0001, respectively). Seven combinations were constructed with T1WI, DWI, and MRCP. The combination of findings on “T1WI or DWI or MRCP” achieved the highest sensitivity of 96.7% and negative predictive value of 99.6%. CONCLUSION: The combination of findings on “T1WI or DWI or MRCP” might be an optimal interpretation model for discriminating small PDAC from control groups in clinical practice.
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spelling pubmed-85712562021-11-08 Abnormal Findings on “T1WI or DWI or MRCP:” An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group Ren, Hainan Mori, Naoko Hirasawa, Minami Hamada, Shin Mugikura, Shunji Masamune, Atsushi Takase, Kei J Clin Imaging Sci Original Research OBJECTIVES: The objectives of the study was to evaluate the diagnostic performance of findings on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and magnetic resonance cholangiopancreatography (MRCP) separately and to identify an optimal Boolean interpretation model for discriminating patients with small pancreatic ductal adenocarcinoma (PDAC) from control groups in clinical practice. MATERIAL AND METHODS: We retrospectively enrolled 30 patients with surgery confirmed small PDAC (≤20 mm) and 302 patients without pancreatic abnormality between April 2008 and February 2020. The presence of masses was evaluated by T1WI, T2WI, and DWI. Abnormality of the main pancreatic duct (MPD) was evaluated by T2WI and MRCP. Multivariate logistic regression analysis was performed to select significant sequences for discriminating the small PDAC and control groups. Boolean operators “OR” or “AND” were used to construct sequence combinations. Diagnostic performances of these sequences and combinations were evaluated by X(2) tests. RESULTS: The sensitivity of T2WI was lowest (20%) for detecting masses. For evaluating MPD abnormality, sensitivity was higher for MRCP than for T2WI (86.7% vs. 53.3%). Multivariate logistic regression analysis showed that T1WI and DWI for detecting the presence of masses and MRCP for evaluating MPD abnormality were significantly associated with differentiation between the two groups (P = 0.0002, P = 0.0484, and P < 0.0001, respectively). Seven combinations were constructed with T1WI, DWI, and MRCP. The combination of findings on “T1WI or DWI or MRCP” achieved the highest sensitivity of 96.7% and negative predictive value of 99.6%. CONCLUSION: The combination of findings on “T1WI or DWI or MRCP” might be an optimal interpretation model for discriminating small PDAC from control groups in clinical practice. Scientific Scholar 2021-10-12 /pmc/articles/PMC8571256/ /pubmed/34754594 http://dx.doi.org/10.25259/JCIS_158_2021 Text en © 2021 Published by Scientific Scholar on behalf of Journal of Clinical Imaging Science https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Research
Ren, Hainan
Mori, Naoko
Hirasawa, Minami
Hamada, Shin
Mugikura, Shunji
Masamune, Atsushi
Takase, Kei
Abnormal Findings on “T1WI or DWI or MRCP:” An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group
title Abnormal Findings on “T1WI or DWI or MRCP:” An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group
title_full Abnormal Findings on “T1WI or DWI or MRCP:” An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group
title_fullStr Abnormal Findings on “T1WI or DWI or MRCP:” An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group
title_full_unstemmed Abnormal Findings on “T1WI or DWI or MRCP:” An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group
title_short Abnormal Findings on “T1WI or DWI or MRCP:” An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group
title_sort abnormal findings on “t1wi or dwi or mrcp:” an effective boolean interpretation model in discriminating small pancreatic ductal adenocarcinoma from control group
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571256/
https://www.ncbi.nlm.nih.gov/pubmed/34754594
http://dx.doi.org/10.25259/JCIS_158_2021
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