Diosmectite inhibits the interaction between SARS-CoV-2 and human enterocytes by trapping viral particles, thereby preventing NF-kappaB activation and CXCL10 secretion

SARS-CoV-2 enters the intestine by the spike protein binding to angiotensin-converting enzyme 2 (ACE2) receptors in enterocyte apical membranes, leading to diarrhea in some patients. Early treatment of COVID-19-associated diarrhea could relieve symptoms and limit viral spread within the gastrointest...

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Detalles Bibliográficos
Autores principales: Poeta, Marco, Cioffi, Valentina, Buccigrossi, Vittoria, Nanayakkara, Merlin, Baggieri, Melissa, Peltrini, Roberto, Amoresano, Angela, Magurano, Fabio, Guarino, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571314/
https://www.ncbi.nlm.nih.gov/pubmed/34741071
http://dx.doi.org/10.1038/s41598-021-01217-2

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