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RAB5A expression is a predictive biomarker for trastuzumab emtansine in breast cancer

HER2 is a predictive biomarker for HER2-targeted therapeutics. For antibody–drug conjugates (ADCs; e.g., trastuzumab emtansine (T-DM1)), HER2 is utilized as a transport gate for cytotoxic agents into the cell. ADC biomarkers may therefore be more complex, also reflecting the intracellular drug trans...

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Detalles Bibliográficos
Autores principales:	Engebraaten, Olav, Yau, Christina, Berg, Kristian, Borgen, Elin, Garred, Øystein, Berstad, Maria E. B., Fremstedal, Ane S. V., DeMichele, Angela, Veer, Laura van ’t, Esserman, Laura, Weyergang, Anette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571323/ https://www.ncbi.nlm.nih.gov/pubmed/34741021 http://dx.doi.org/10.1038/s41467-021-26018-z

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