The Development of Pharmacological Therapies for Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that currently has no cure. The aged population is growing globally, creating an urgent need for more promising therapies for this debilitating disease. Much effort has been made in recent decades, and the field is highly dynamic,...

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Autores principales: Lin, Ping, Sun, Junyu, Cheng, Qi, Yang, Yue, Cordato, Dennis, Gao, Jianqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571471/
https://www.ncbi.nlm.nih.gov/pubmed/34532845
http://dx.doi.org/10.1007/s40120-021-00282-z
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author Lin, Ping
Sun, Junyu
Cheng, Qi
Yang, Yue
Cordato, Dennis
Gao, Jianqun
author_facet Lin, Ping
Sun, Junyu
Cheng, Qi
Yang, Yue
Cordato, Dennis
Gao, Jianqun
author_sort Lin, Ping
collection PubMed
description Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that currently has no cure. The aged population is growing globally, creating an urgent need for more promising therapies for this debilitating disease. Much effort has been made in recent decades, and the field is highly dynamic, with numerous trials. The main focus of these trials includes disease modification and symptomatic treatment. Some have shown beneficial outcomes, while others have shown no significant benefits. Here, we cover the outcome of recently published AD clinical trials, as well as the mechanism of action of these therapeutical agents, to re-think drug development strategies and directions for future studies.
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spelling pubmed-85714712021-11-15 The Development of Pharmacological Therapies for Alzheimer’s Disease Lin, Ping Sun, Junyu Cheng, Qi Yang, Yue Cordato, Dennis Gao, Jianqun Neurol Ther Review Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that currently has no cure. The aged population is growing globally, creating an urgent need for more promising therapies for this debilitating disease. Much effort has been made in recent decades, and the field is highly dynamic, with numerous trials. The main focus of these trials includes disease modification and symptomatic treatment. Some have shown beneficial outcomes, while others have shown no significant benefits. Here, we cover the outcome of recently published AD clinical trials, as well as the mechanism of action of these therapeutical agents, to re-think drug development strategies and directions for future studies. Springer Healthcare 2021-09-16 /pmc/articles/PMC8571471/ /pubmed/34532845 http://dx.doi.org/10.1007/s40120-021-00282-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Lin, Ping
Sun, Junyu
Cheng, Qi
Yang, Yue
Cordato, Dennis
Gao, Jianqun
The Development of Pharmacological Therapies for Alzheimer’s Disease
title The Development of Pharmacological Therapies for Alzheimer’s Disease
title_full The Development of Pharmacological Therapies for Alzheimer’s Disease
title_fullStr The Development of Pharmacological Therapies for Alzheimer’s Disease
title_full_unstemmed The Development of Pharmacological Therapies for Alzheimer’s Disease
title_short The Development of Pharmacological Therapies for Alzheimer’s Disease
title_sort development of pharmacological therapies for alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571471/
https://www.ncbi.nlm.nih.gov/pubmed/34532845
http://dx.doi.org/10.1007/s40120-021-00282-z
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