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Cost‐minimization analysis of a wearable cardioverter defibrillator in adult patients undergoing ICD explant procedures: Clinical and economic implications

AIMS: Patients with permanently increased risk of sudden cardiac death (SCD) can be protected by implantable cardioverter defibrillators (ICD). If an ICD must be removed due to infection, for example, immediate reimplantation might not be possible or indicated. The wearable cardioverter defibrillato...

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Autores principales: Boriani, Giuseppe, Mantovani, Lorenzo Giovanni, Cortesi, Paolo Angelo, De Ponti, Roberto, D'Onofrio, Antonio, Arena, Giuseppe, Curnis, Antonio, Forleo, Giovanni, Guerra, Federico, Porcu, Maurizio, Sgarito, Giuseppe, Botto, Giovanni Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571546/
https://www.ncbi.nlm.nih.gov/pubmed/34427926
http://dx.doi.org/10.1002/clc.23709
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author Boriani, Giuseppe
Mantovani, Lorenzo Giovanni
Cortesi, Paolo Angelo
De Ponti, Roberto
D'Onofrio, Antonio
Arena, Giuseppe
Curnis, Antonio
Forleo, Giovanni
Guerra, Federico
Porcu, Maurizio
Sgarito, Giuseppe
Botto, Giovanni Luca
author_facet Boriani, Giuseppe
Mantovani, Lorenzo Giovanni
Cortesi, Paolo Angelo
De Ponti, Roberto
D'Onofrio, Antonio
Arena, Giuseppe
Curnis, Antonio
Forleo, Giovanni
Guerra, Federico
Porcu, Maurizio
Sgarito, Giuseppe
Botto, Giovanni Luca
author_sort Boriani, Giuseppe
collection PubMed
description AIMS: Patients with permanently increased risk of sudden cardiac death (SCD) can be protected by implantable cardioverter defibrillators (ICD). If an ICD must be removed due to infection, for example, immediate reimplantation might not be possible or indicated. The wearable cardioverter defibrillator (WCD) is an established, safe and effective solution to protect patients from SCD during this high‐risk bridging period. Very few economic evaluations on WCD use are currently available. METHODS: We conducted a systematic review to evaluate the available evidence of WCD in patients undergoing ICD explant/lead extraction. Additionally, a decision model was developed to compare use and costs of the WCD with standard therapy (in‐hospital stay). For this purpose, a cost‐minimization analysis was conducted, and complemented by a one‐way sensitivity analysis. RESULTS: In the base case scenario, the WCD was less expensive compared to standard therapy. The cost‐minimization analysis showed a cost reduction of €1782 per patient using the WCD. If costs of standard care were changed, cost savings associated with the WCD varied from €3500 to €0, assuming costs for standard care of €6800 to €3600. CONCLUSION: After ICD explantation, patients can be safely and effectively protected from SCD after hospital discharge through WCD utilization. Furthermore, the use of a WCD for this patient group is cost saving when compared to standard therapy.
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spelling pubmed-85715462021-11-10 Cost‐minimization analysis of a wearable cardioverter defibrillator in adult patients undergoing ICD explant procedures: Clinical and economic implications Boriani, Giuseppe Mantovani, Lorenzo Giovanni Cortesi, Paolo Angelo De Ponti, Roberto D'Onofrio, Antonio Arena, Giuseppe Curnis, Antonio Forleo, Giovanni Guerra, Federico Porcu, Maurizio Sgarito, Giuseppe Botto, Giovanni Luca Clin Cardiol Clinical Investigations AIMS: Patients with permanently increased risk of sudden cardiac death (SCD) can be protected by implantable cardioverter defibrillators (ICD). If an ICD must be removed due to infection, for example, immediate reimplantation might not be possible or indicated. The wearable cardioverter defibrillator (WCD) is an established, safe and effective solution to protect patients from SCD during this high‐risk bridging period. Very few economic evaluations on WCD use are currently available. METHODS: We conducted a systematic review to evaluate the available evidence of WCD in patients undergoing ICD explant/lead extraction. Additionally, a decision model was developed to compare use and costs of the WCD with standard therapy (in‐hospital stay). For this purpose, a cost‐minimization analysis was conducted, and complemented by a one‐way sensitivity analysis. RESULTS: In the base case scenario, the WCD was less expensive compared to standard therapy. The cost‐minimization analysis showed a cost reduction of €1782 per patient using the WCD. If costs of standard care were changed, cost savings associated with the WCD varied from €3500 to €0, assuming costs for standard care of €6800 to €3600. CONCLUSION: After ICD explantation, patients can be safely and effectively protected from SCD after hospital discharge through WCD utilization. Furthermore, the use of a WCD for this patient group is cost saving when compared to standard therapy. Wiley Periodicals, Inc. 2021-08-24 /pmc/articles/PMC8571546/ /pubmed/34427926 http://dx.doi.org/10.1002/clc.23709 Text en © 2021 The Authors. Clinical Cardiology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigations
Boriani, Giuseppe
Mantovani, Lorenzo Giovanni
Cortesi, Paolo Angelo
De Ponti, Roberto
D'Onofrio, Antonio
Arena, Giuseppe
Curnis, Antonio
Forleo, Giovanni
Guerra, Federico
Porcu, Maurizio
Sgarito, Giuseppe
Botto, Giovanni Luca
Cost‐minimization analysis of a wearable cardioverter defibrillator in adult patients undergoing ICD explant procedures: Clinical and economic implications
title Cost‐minimization analysis of a wearable cardioverter defibrillator in adult patients undergoing ICD explant procedures: Clinical and economic implications
title_full Cost‐minimization analysis of a wearable cardioverter defibrillator in adult patients undergoing ICD explant procedures: Clinical and economic implications
title_fullStr Cost‐minimization analysis of a wearable cardioverter defibrillator in adult patients undergoing ICD explant procedures: Clinical and economic implications
title_full_unstemmed Cost‐minimization analysis of a wearable cardioverter defibrillator in adult patients undergoing ICD explant procedures: Clinical and economic implications
title_short Cost‐minimization analysis of a wearable cardioverter defibrillator in adult patients undergoing ICD explant procedures: Clinical and economic implications
title_sort cost‐minimization analysis of a wearable cardioverter defibrillator in adult patients undergoing icd explant procedures: clinical and economic implications
topic Clinical Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571546/
https://www.ncbi.nlm.nih.gov/pubmed/34427926
http://dx.doi.org/10.1002/clc.23709
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