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A single aromatic residue in sgp130Fc/olamkicept allows the discrimination between interleukin-6 and interleukin-11 trans-signaling

Blocking the activity of cytokines is an efficient strategy to combat inflammatory diseases. Interleukin-6 (IL-6) fulfills its pro-inflammatory properties via its soluble receptor (IL-6 trans-signaling). The selective trans-signaling inhibitor olamkicept (sgp130Fc) is currently in clinical developme...

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Detalles Bibliográficos
Autores principales:	Lokau, Juliane, Garbers, Yvonne, Grötzinger, Joachim, Garbers, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571719/ https://www.ncbi.nlm.nih.gov/pubmed/34765926 http://dx.doi.org/10.1016/j.isci.2021.103309

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