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Frequency and factors associated with proteinuria in COVID-19 patients: a cross-sectional study
Proteinuria is a marker of severity and poor outcome of patients in intensive care unit (ICU). The objective of this study was to determine the frequency of proteinuria and the risk factors associated with proteinuria in Congolese COVID-19 patients. The present cross sectional study of proteinuria s...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The African Field Epidemiology Network
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571933/ https://www.ncbi.nlm.nih.gov/pubmed/34795818 http://dx.doi.org/10.11604/pamj.2021.40.37.29796 |
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author | Nlandu, Yannick Mayamba Sakaji, Theodore-Junior Manyka Engole, Yannick Mompango Mboliasa, Pitchouna Marie-France Ingole Bena, Dauphin Mulumba Abatha, Jessy Mukamamvula Nkumu, Jean-Robert Mpoke Nkodila, Aliocha Natuhoyila Van Eckout, Karel Kalifa, Golan Ahmed, Rodolphe Bukabau, Justine Busanga |
author_facet | Nlandu, Yannick Mayamba Sakaji, Theodore-Junior Manyka Engole, Yannick Mompango Mboliasa, Pitchouna Marie-France Ingole Bena, Dauphin Mulumba Abatha, Jessy Mukamamvula Nkumu, Jean-Robert Mpoke Nkodila, Aliocha Natuhoyila Van Eckout, Karel Kalifa, Golan Ahmed, Rodolphe Bukabau, Justine Busanga |
author_sort | Nlandu, Yannick Mayamba |
collection | PubMed |
description | Proteinuria is a marker of severity and poor outcome of patients in intensive care unit (ICU). The objective of this study was to determine the frequency of proteinuria and the risk factors associated with proteinuria in Congolese COVID-19 patients. The present cross sectional study of proteinuria status is a post hoc analysis of data from 80 COVID-19 patients admitted at Kinshasa Medical Center (KMC) from March 10(th) to July 10(th), 2020. The population under study came from all adult inpatients (≥18 years old) with a laboratory diagnosis by polymerase chain reaction (PCR) of COVID-19 were selected and divided into two groups (positive proteinuria and negative proteinuria group). Logistic regression models helped to identify the factors associated with proteinuria. The P value significance level was 0.05. Among 80 patients who tested positive for SARS-CoV-2 RT-PCR, 55% had proteinuria. The mean age was 55.2 ± 12.8 years. Fourty-seven patients (58.8%) had history of hypertension and 26 patients (32.5%) diabetes. Multivariable analysis showed age ≥ 65 years (aOR 5,04; 95% CI: 1.51-16.78), diabetes (aOR 3,15; 95% CI: 1.14-8.72), ASAT >40 UI/L (aOR 7,08; 95% CI: 2.40-20.87), ferritin >300 (aOR 13,47; 95% CI: 1.56-26.25) as factors independently associated with proteinuria in COVID-19 patients. Proteinuria is common in Congolese COVID-19 patients and is associated with age, diabetes, ferritin and aspartate aminotransferase (ASAT). |
format | Online Article Text |
id | pubmed-8571933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-85719332021-11-17 Frequency and factors associated with proteinuria in COVID-19 patients: a cross-sectional study Nlandu, Yannick Mayamba Sakaji, Theodore-Junior Manyka Engole, Yannick Mompango Mboliasa, Pitchouna Marie-France Ingole Bena, Dauphin Mulumba Abatha, Jessy Mukamamvula Nkumu, Jean-Robert Mpoke Nkodila, Aliocha Natuhoyila Van Eckout, Karel Kalifa, Golan Ahmed, Rodolphe Bukabau, Justine Busanga Pan Afr Med J Short Communication Proteinuria is a marker of severity and poor outcome of patients in intensive care unit (ICU). The objective of this study was to determine the frequency of proteinuria and the risk factors associated with proteinuria in Congolese COVID-19 patients. The present cross sectional study of proteinuria status is a post hoc analysis of data from 80 COVID-19 patients admitted at Kinshasa Medical Center (KMC) from March 10(th) to July 10(th), 2020. The population under study came from all adult inpatients (≥18 years old) with a laboratory diagnosis by polymerase chain reaction (PCR) of COVID-19 were selected and divided into two groups (positive proteinuria and negative proteinuria group). Logistic regression models helped to identify the factors associated with proteinuria. The P value significance level was 0.05. Among 80 patients who tested positive for SARS-CoV-2 RT-PCR, 55% had proteinuria. The mean age was 55.2 ± 12.8 years. Fourty-seven patients (58.8%) had history of hypertension and 26 patients (32.5%) diabetes. Multivariable analysis showed age ≥ 65 years (aOR 5,04; 95% CI: 1.51-16.78), diabetes (aOR 3,15; 95% CI: 1.14-8.72), ASAT >40 UI/L (aOR 7,08; 95% CI: 2.40-20.87), ferritin >300 (aOR 13,47; 95% CI: 1.56-26.25) as factors independently associated with proteinuria in COVID-19 patients. Proteinuria is common in Congolese COVID-19 patients and is associated with age, diabetes, ferritin and aspartate aminotransferase (ASAT). The African Field Epidemiology Network 2021-09-14 /pmc/articles/PMC8571933/ /pubmed/34795818 http://dx.doi.org/10.11604/pamj.2021.40.37.29796 Text en Copyright: Yannick Mayamba Nlandu et al. https://creativecommons.org/licenses/by/4.0/The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Nlandu, Yannick Mayamba Sakaji, Theodore-Junior Manyka Engole, Yannick Mompango Mboliasa, Pitchouna Marie-France Ingole Bena, Dauphin Mulumba Abatha, Jessy Mukamamvula Nkumu, Jean-Robert Mpoke Nkodila, Aliocha Natuhoyila Van Eckout, Karel Kalifa, Golan Ahmed, Rodolphe Bukabau, Justine Busanga Frequency and factors associated with proteinuria in COVID-19 patients: a cross-sectional study |
title | Frequency and factors associated with proteinuria in COVID-19 patients: a cross-sectional study |
title_full | Frequency and factors associated with proteinuria in COVID-19 patients: a cross-sectional study |
title_fullStr | Frequency and factors associated with proteinuria in COVID-19 patients: a cross-sectional study |
title_full_unstemmed | Frequency and factors associated with proteinuria in COVID-19 patients: a cross-sectional study |
title_short | Frequency and factors associated with proteinuria in COVID-19 patients: a cross-sectional study |
title_sort | frequency and factors associated with proteinuria in covid-19 patients: a cross-sectional study |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571933/ https://www.ncbi.nlm.nih.gov/pubmed/34795818 http://dx.doi.org/10.11604/pamj.2021.40.37.29796 |
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