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COVID-19 adenovirus vaccine triggers antibodies against PF4 complexes to activate complement and platelets

BACKGROUND: Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare coagulation disorder reported after administration of COVID-19 adenovirus-vectored vaccines. VITT is mediated by anti-platelet factor 4 (PF4) antibodies activating platelets through the Fcγ-receptor II (FcγRII), and it is assoc...

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Detalles Bibliográficos
Autores principales:	Pitkänen, Hanna H., Jouppila, Annukka, Helin, Tuukka, Dulipati, Vinaya, Kotimaa, Juha, Meri, Seppo, Kantele, Anu, Jalkanen, Pinja, Julkunen, Ilkka, Lassila, Riitta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2021
Materias:	Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571998/ https://www.ncbi.nlm.nih.gov/pubmed/34768097 http://dx.doi.org/10.1016/j.thromres.2021.10.027

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