Cargando…

Pleiotropic predisposition to Alzheimer’s disease and educational attainment: insights from the summary statistics analysis

Epidemiological studies report beneficial associations of higher educational attainment (EDU) with Alzheimer’s disease (AD). Prior genome-wide association studies (GWAS) also reported variants associated with AD and EDU separately. The analysis of pleiotropic associations with these phenotypes may s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kulminski, Alexander M., Loiko, Elena, Loika, Yury, Culminskaya, Irina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572080/ https://www.ncbi.nlm.nih.gov/pubmed/34743297 http://dx.doi.org/10.1007/s11357-021-00484-1

Ejemplares similares

Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
por: Loika, Yury, et al.
Publicado: (2021)

Pleiotropy of Alzheimer’s Disease and Educational Attainment: Insights from the Summary Statistics
por: Loika, Yury, et al.
Publicado: (2021)

Exome-Wide Association Study Identified Clusters of Pleiotropic Genetic Associations with Alzheimer’s Disease and Thirteen Cardiovascular Traits
por: Loika, Yury, et al.
Publicado: (2023)

EXOME-WIDE STUDY IDENTIFIED 12 PLEIOTROPIC LOCI ASSOCIATED WITH ALZHEIMER’S AND CARDIOVASCULAR DISEASE RISKS
por: Loika, Yury, et al.
Publicado: (2022)

Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer’s disease biomarkers
por: Kulminski, Alexander M., et al.
Publicado: (2022)

Haplotype architecture of the Alzheimer's risk in the APOE region via co‐skewness
por: Kulminski, Alexander M., et al.
Publicado: (2020)

Apolipoprotein E region molecular signatures of Alzheimer's disease
por: Kulminski, Alexander M., et al.
Publicado: (2018)

Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms
por: Kulminski, Alexander M., et al.
Publicado: (2019)

Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus
por: Loika, Yury, et al.
Publicado: (2023)

An Approach to Identify New Pleiotropic Genetic Loci From Publicly Available Univariate GWAS Results
por: Loika, Yury, et al.
Publicado: (2020)

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality
por: Kulminski, Alexander M., et al.
Publicado: (2016)

GENOME-WIDE META-ANALYSIS SUPPORTS HETEROGENEITY IN POLYGENIC ARCHITECTURE OF DISABILITY
por: Kulminski, Alexander, et al.
Publicado: (2019)

Genetic and regulatory architecture of Alzheimer's disease in the APOE region
por: Kulminski, Alexander M., et al.
Publicado: (2020)

Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases
por: He, Liang, et al.
Publicado: (2016)

Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases
por: He, Liang, et al.
Publicado: (2018)

Allele-specific analysis reveals exon- and cell-type-specific regulatory effects of Alzheimer’s disease-associated genetic variants
por: He, Liang, et al.
Publicado: (2022)

Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency
por: Kulminski, Alexander M., et al.
Publicado: (2016)

Strong impact of natural-selection–free heterogeneity in genetics of age-related phenotypes
por: Kulminski, Alexander M., et al.
Publicado: (2018)

APOE ɛ4 allele and TOMM40‐APOC1 variants jointly contribute to survival to older ages
por: Kulminski, Alexander M., et al.
Publicado: (2022)

Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart‐related traits
por: Kulminski, Alexander M., et al.
Publicado: (2016)

Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk
por: Nazarian, Alireza, et al.
Publicado: (2022)

Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities
por: Nazarian, Alireza, et al.
Publicado: (2019)

Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer’s disease
por: He, Liang, et al.
Publicado: (2021)

Independent associations of TOMM40 and APOE variants with body mass index
por: Kulminski, Alexander M., et al.
Publicado: (2018)

Integrated Analysis of Summary Statistics to Identify Pleiotropic Genes and Pathways for the Comorbidity of Schizophrenia and Cardiometabolic Disease
por: Liu, Hao, et al.
Publicado: (2020)

Summary statistics-based association test for identifying the pleiotropic effects with set of genetic variants
por: Bu, Deliang, et al.
Publicado: (2023)

Summary-Based Methylome-Wide Association Analyses Suggest Potential Genetically Driven Epigenetic Heterogeneity of Alzheimer’s Disease
por: Nazarian, Alireza, et al.
Publicado: (2020)

Genomic variation in educational attainment modifies Alzheimer disease risk
por: Raghavan, Neha S., et al.
Publicado: (2019)

Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics
por: Morrison, Jean, et al.
Publicado: (2020)

Potential Pleiotropic Genes and Shared Biological Pathways in Epilepsy and Depression Based on GWAS Summary Statistics
por: Lin, Han, et al.
Publicado: (2022)

A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics
por: Lu, Haojie, et al.
Publicado: (2021)

Improved Detection of Potentially Pleiotropic Genes in Coronary Artery Disease and Chronic Kidney Disease Using GWAS Summary Statistics
por: Chen, Haimiao, et al.
Publicado: (2020)

Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease
por: Bryzgalov, Leonid O., et al.
Publicado: (2023)

APOE alleles modulate associations of plasma metabolites with variants from multiple genes on chromosome 19q13.3
por: Nazarian, Alireza, et al.
Publicado: (2022)

Genetics and educational attainment
por: Cesarini, David, et al.
Publicado: (2017)

Why does melanoma metastasize into the brain? Genes with pleiotropic effects might be the key
por: Yashin, Anatoliy I., et al.
Publicado: (2013)

Educational attainment, structural brain reserve and Alzheimer’s disease: a Mendelian randomization analysis
por: Seyedsalehi, Aida, et al.
Publicado: (2022)

Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer’s disease
por: Langella, Stephanie, et al.
Publicado: (2023)

Why Pleiotropic Interventions are Needed for Alzheimer's Disease
por: Frautschy, Sally A., et al.
Publicado: (2010)

Pleiotropic Protective Effects of Phytochemicals in Alzheimer's Disease
por: Davinelli, Sergio, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_kta648p0sisbtve653qu883hre