Linagliptin Inhibits Interleukin-6 Production Through Toll-Like Receptor 4 Complex and Lipopolysaccharide-Binding Protein Independent Pathway in vitro Model

PURPOSE: Lipopolysaccharides (LPS) induce inflammation by binding to the Toll-like receptor (TLR) 4 complex, including LPS-binding protein (LBP). The anti-inflammatory effects of linagliptin in LPS-induced inflammation in the TLR4-independent pathway have not been examined before. We examined the an...

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Detalles Bibliográficos
Autores principales: Saito, Hiroshi, Nakamura, Yuya, Inagaki, Masahiro, Yamadera, Shiho, Misawa, Hideo, Sato, Naoki, Oguchi, Tatsunori, Inagaki, Takae, Tsuji, Yuya, Tsuji, Mayumi, Ohsawa, Isao, Gotoh, Hiromichi, Kiuchi, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572089/
https://www.ncbi.nlm.nih.gov/pubmed/34754214
http://dx.doi.org/10.2147/JIR.S326382

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