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Mini-review: Synaptojanin 1 and its implications in membrane trafficking

This mini-review aims to summarize a growing body of literature on synaptojanin 1 (Synj1), a phosphoinositide phosphatase that was initially known to have a prominent role in synaptic vesicle recycling. Synj1 is coded by the SYNJ1 gene, whose mutations and variants are associated with an increasing...

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Autores principales: Choudhry, Hassaam, Aggarwal, Meha, Pan, Ping-Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572151/
https://www.ncbi.nlm.nih.gov/pubmed/34637856
http://dx.doi.org/10.1016/j.neulet.2021.136288
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author Choudhry, Hassaam
Aggarwal, Meha
Pan, Ping-Yue
author_facet Choudhry, Hassaam
Aggarwal, Meha
Pan, Ping-Yue
author_sort Choudhry, Hassaam
collection PubMed
description This mini-review aims to summarize a growing body of literature on synaptojanin 1 (Synj1), a phosphoinositide phosphatase that was initially known to have a prominent role in synaptic vesicle recycling. Synj1 is coded by the SYNJ1 gene, whose mutations and variants are associated with an increasing number of neurological disorders. To better understand the mechanistic role of Synj1 in disease pathogenesis, we review details of phosphoinositide signaling pathways and the reported involvement of Synj1 in membrane trafficking with a specific focus on Parkinson’s disease (PD). Recent studies have tremendously advanced our understanding of Synj1 protein structure and function while broadening our view of how Synj1 regulates synaptic membrane trafficking and endosomal trafficking in various organisms and cell types. A growing body of evidence points to inefficient membrane trafficking as key pathogenic mechanisms in neurodegenerative diseases associated with abnormal Synj1 expression. Despite significant progress made in the field, the mechanism by which Synj1 connects to trafficking, signaling, and pathogenesis is lacking and remains to be addressed.
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spelling pubmed-85721512021-11-20 Mini-review: Synaptojanin 1 and its implications in membrane trafficking Choudhry, Hassaam Aggarwal, Meha Pan, Ping-Yue Neurosci Lett Article This mini-review aims to summarize a growing body of literature on synaptojanin 1 (Synj1), a phosphoinositide phosphatase that was initially known to have a prominent role in synaptic vesicle recycling. Synj1 is coded by the SYNJ1 gene, whose mutations and variants are associated with an increasing number of neurological disorders. To better understand the mechanistic role of Synj1 in disease pathogenesis, we review details of phosphoinositide signaling pathways and the reported involvement of Synj1 in membrane trafficking with a specific focus on Parkinson’s disease (PD). Recent studies have tremendously advanced our understanding of Synj1 protein structure and function while broadening our view of how Synj1 regulates synaptic membrane trafficking and endosomal trafficking in various organisms and cell types. A growing body of evidence points to inefficient membrane trafficking as key pathogenic mechanisms in neurodegenerative diseases associated with abnormal Synj1 expression. Despite significant progress made in the field, the mechanism by which Synj1 connects to trafficking, signaling, and pathogenesis is lacking and remains to be addressed. 2021-10-09 2021-11-20 /pmc/articles/PMC8572151/ /pubmed/34637856 http://dx.doi.org/10.1016/j.neulet.2021.136288 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Choudhry, Hassaam
Aggarwal, Meha
Pan, Ping-Yue
Mini-review: Synaptojanin 1 and its implications in membrane trafficking
title Mini-review: Synaptojanin 1 and its implications in membrane trafficking
title_full Mini-review: Synaptojanin 1 and its implications in membrane trafficking
title_fullStr Mini-review: Synaptojanin 1 and its implications in membrane trafficking
title_full_unstemmed Mini-review: Synaptojanin 1 and its implications in membrane trafficking
title_short Mini-review: Synaptojanin 1 and its implications in membrane trafficking
title_sort mini-review: synaptojanin 1 and its implications in membrane trafficking
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572151/
https://www.ncbi.nlm.nih.gov/pubmed/34637856
http://dx.doi.org/10.1016/j.neulet.2021.136288
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