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Psychometric Evaluation of ITP Life Quality Index (ILQI) in a Global Survey of Patients with Immune Thrombocytopenia
INTRODUCTION: Immune thrombocytopenia (ITP) is an autoimmune disorder caused by immunologic destruction of otherwise normal platelets. Patients and physicians differ in their views pertaining to the limitations imposed on patients’ daily lives by ITP and its treatment. Poor understanding of ITP symp...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Healthcare
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572218/ https://www.ncbi.nlm.nih.gov/pubmed/34704193 http://dx.doi.org/10.1007/s12325-021-01934-0 |
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author | Viana, Ricardo D’Alessio, Denise Grant, Laura Cooper, Nichola Arnold, Donald Morgan, Mervyn Provan, Drew Cuker, Adam Hill, Quentin A. Tomiyama, Yoshiaki Ghanima, Waleed |
author_facet | Viana, Ricardo D’Alessio, Denise Grant, Laura Cooper, Nichola Arnold, Donald Morgan, Mervyn Provan, Drew Cuker, Adam Hill, Quentin A. Tomiyama, Yoshiaki Ghanima, Waleed |
author_sort | Viana, Ricardo |
collection | PubMed |
description | INTRODUCTION: Immune thrombocytopenia (ITP) is an autoimmune disorder caused by immunologic destruction of otherwise normal platelets. Patients and physicians differ in their views pertaining to the limitations imposed on patients’ daily lives by ITP and its treatment. Poor understanding of ITP symptoms can result in misdiagnosis and complex treatment patterns, and affect patient health-related quality of life (HRQoL). The ITP Life Quality Index (ILQI) is a 10-item patient-reported outcome measure developed for clinical practice to aid discussions between patients and physicians. This research aimed to validate the psychometric properties of the ILQI using data collected in the ITP World Impact Survey (I-WISh). METHODS: I-WISh data containing responses to the ILQI from 1507 patients with ITP across 13 countries worldwide was subject to psychometric analysis to evaluate the structure, reliability and validity of the ILQI and assess scoring cut-offs. RESULTS: The ILQI has an overarching unidimensional structure, supporting a total score including all 10 items. Reliability was supported (Cronbach’s alpha = 0.90). ILQI scores monotonically increased with ITP severity. ILQI scores correlated with measures of fatigue and emotional well-being, supporting construct validity. Differential item functioning (DIF) analyses showed that ILQI item responses were interpreted similarly between the USA and other Western countries. It was suggested that previous clinical cut-off score of 20 for “impaired HRQoL” was reduced to 17 and a cut-off of 23–25 (rather than 30) was suggested to assess “significantly impaired HRQoL”. CONCLUSION: The validity and reliability of the ILQI to assess HRQoL of patients with ITP is supported. The revised cut-off scores for the ILQI will aid patient-centric decision-making. |
format | Online Article Text |
id | pubmed-8572218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-85722182021-11-15 Psychometric Evaluation of ITP Life Quality Index (ILQI) in a Global Survey of Patients with Immune Thrombocytopenia Viana, Ricardo D’Alessio, Denise Grant, Laura Cooper, Nichola Arnold, Donald Morgan, Mervyn Provan, Drew Cuker, Adam Hill, Quentin A. Tomiyama, Yoshiaki Ghanima, Waleed Adv Ther Original Research INTRODUCTION: Immune thrombocytopenia (ITP) is an autoimmune disorder caused by immunologic destruction of otherwise normal platelets. Patients and physicians differ in their views pertaining to the limitations imposed on patients’ daily lives by ITP and its treatment. Poor understanding of ITP symptoms can result in misdiagnosis and complex treatment patterns, and affect patient health-related quality of life (HRQoL). The ITP Life Quality Index (ILQI) is a 10-item patient-reported outcome measure developed for clinical practice to aid discussions between patients and physicians. This research aimed to validate the psychometric properties of the ILQI using data collected in the ITP World Impact Survey (I-WISh). METHODS: I-WISh data containing responses to the ILQI from 1507 patients with ITP across 13 countries worldwide was subject to psychometric analysis to evaluate the structure, reliability and validity of the ILQI and assess scoring cut-offs. RESULTS: The ILQI has an overarching unidimensional structure, supporting a total score including all 10 items. Reliability was supported (Cronbach’s alpha = 0.90). ILQI scores monotonically increased with ITP severity. ILQI scores correlated with measures of fatigue and emotional well-being, supporting construct validity. Differential item functioning (DIF) analyses showed that ILQI item responses were interpreted similarly between the USA and other Western countries. It was suggested that previous clinical cut-off score of 20 for “impaired HRQoL” was reduced to 17 and a cut-off of 23–25 (rather than 30) was suggested to assess “significantly impaired HRQoL”. CONCLUSION: The validity and reliability of the ILQI to assess HRQoL of patients with ITP is supported. The revised cut-off scores for the ILQI will aid patient-centric decision-making. Springer Healthcare 2021-10-27 2021 /pmc/articles/PMC8572218/ /pubmed/34704193 http://dx.doi.org/10.1007/s12325-021-01934-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Viana, Ricardo D’Alessio, Denise Grant, Laura Cooper, Nichola Arnold, Donald Morgan, Mervyn Provan, Drew Cuker, Adam Hill, Quentin A. Tomiyama, Yoshiaki Ghanima, Waleed Psychometric Evaluation of ITP Life Quality Index (ILQI) in a Global Survey of Patients with Immune Thrombocytopenia |
title | Psychometric Evaluation of ITP Life Quality Index (ILQI) in a Global Survey of Patients with Immune Thrombocytopenia |
title_full | Psychometric Evaluation of ITP Life Quality Index (ILQI) in a Global Survey of Patients with Immune Thrombocytopenia |
title_fullStr | Psychometric Evaluation of ITP Life Quality Index (ILQI) in a Global Survey of Patients with Immune Thrombocytopenia |
title_full_unstemmed | Psychometric Evaluation of ITP Life Quality Index (ILQI) in a Global Survey of Patients with Immune Thrombocytopenia |
title_short | Psychometric Evaluation of ITP Life Quality Index (ILQI) in a Global Survey of Patients with Immune Thrombocytopenia |
title_sort | psychometric evaluation of itp life quality index (ilqi) in a global survey of patients with immune thrombocytopenia |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572218/ https://www.ncbi.nlm.nih.gov/pubmed/34704193 http://dx.doi.org/10.1007/s12325-021-01934-0 |
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