LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome

Extracellular vesicles (EVs) have emerged as important vectors of intercellular dialogue. High mobility group box protein 1 (HMGB1) is a typical damage-associated molecular pattern (DAMP) molecule, which is cytotoxic and leads to cell death and tissue injury. Whether EVs are involved in the release...

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Detalles Bibliográficos
Autores principales: Wang, Guozhen, Jin, Siyi, Huang, Weichang, Li, Yang, Wang, Jun, Ling, Xuguang, Huang, Yun, Hu, Ye, Li, Congcong, Meng, Ying, Li, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572226/
https://www.ncbi.nlm.nih.gov/pubmed/34743181
http://dx.doi.org/10.1038/s41420-021-00729-0

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