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Functional delivery of lncRNA TUG1 by endothelial progenitor cells derived extracellular vesicles confers anti-inflammatory macrophage polarization in sepsis via impairing miR-9-5p-targeted SIRT1 inhibition

The delivery of biomolecules by extracellular vesicles (EVs) derived from endothelial progenitor cells (EPCs) has been proven to ameliorate sepsis, yet the therapeutic mechanism remains to be elucidated. Taurine upregulated gene 1 (TUG1) is a long noncoding RNA (lncRNA) that is downregulated in seps...

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Detalles Bibliográficos
Autores principales:	Ma, Wentao, Zhang, Weihong, Cui, Bing, Gao, Jing, Liu, Qiuhong, Yao, Mengying, Ning, Hanbing, Xing, Lihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572288/ https://www.ncbi.nlm.nih.gov/pubmed/34743197 http://dx.doi.org/10.1038/s41419-021-04117-5

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