Cushing’s Syndrome Due to a Functional Thymic Neuroendocrine Tumor in Multiple Endocrine Neoplasia Type 1 Syndrome

Multiple endocrine neoplasia type 1 (MEN 1) syndrome is characterized by endocrinopathies and could be associated with thymic neuroendocrine tumors (NET). On rare occasions, they can be functional adrenocorticotropic hormone-secreting thymic carcinoid leading to Cushing's syndrome. In this repo...

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Detalles Bibliográficos
Autores principales: Asemota, Iriagbonse R, Ajiboye, Oyintayo, Nwaichi, Chineme, Mbachi, Chimezie, Mba, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572323/
https://www.ncbi.nlm.nih.gov/pubmed/34760427
http://dx.doi.org/10.7759/cureus.18590
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author Asemota, Iriagbonse R
Ajiboye, Oyintayo
Nwaichi, Chineme
Mbachi, Chimezie
Mba, Benjamin
author_facet Asemota, Iriagbonse R
Ajiboye, Oyintayo
Nwaichi, Chineme
Mbachi, Chimezie
Mba, Benjamin
author_sort Asemota, Iriagbonse R
collection PubMed
description Multiple endocrine neoplasia type 1 (MEN 1) syndrome is characterized by endocrinopathies and could be associated with thymic neuroendocrine tumors (NET). On rare occasions, they can be functional adrenocorticotropic hormone-secreting thymic carcinoid leading to Cushing's syndrome. In this report, we describe a case of adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome due to a thymic NET associated with MEN type 1 syndrome. We highlight its aggressive clinical course, the premise for a high index of suspicion for an ectopic ACTH secretion, and the need for early surgical resection combined with medical therapy and alternative treatments.
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spelling pubmed-85723232021-11-09 Cushing’s Syndrome Due to a Functional Thymic Neuroendocrine Tumor in Multiple Endocrine Neoplasia Type 1 Syndrome Asemota, Iriagbonse R Ajiboye, Oyintayo Nwaichi, Chineme Mbachi, Chimezie Mba, Benjamin Cureus Endocrinology/Diabetes/Metabolism Multiple endocrine neoplasia type 1 (MEN 1) syndrome is characterized by endocrinopathies and could be associated with thymic neuroendocrine tumors (NET). On rare occasions, they can be functional adrenocorticotropic hormone-secreting thymic carcinoid leading to Cushing's syndrome. In this report, we describe a case of adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome due to a thymic NET associated with MEN type 1 syndrome. We highlight its aggressive clinical course, the premise for a high index of suspicion for an ectopic ACTH secretion, and the need for early surgical resection combined with medical therapy and alternative treatments. Cureus 2021-10-07 /pmc/articles/PMC8572323/ /pubmed/34760427 http://dx.doi.org/10.7759/cureus.18590 Text en Copyright © 2021, Asemota et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Asemota, Iriagbonse R
Ajiboye, Oyintayo
Nwaichi, Chineme
Mbachi, Chimezie
Mba, Benjamin
Cushing’s Syndrome Due to a Functional Thymic Neuroendocrine Tumor in Multiple Endocrine Neoplasia Type 1 Syndrome
title Cushing’s Syndrome Due to a Functional Thymic Neuroendocrine Tumor in Multiple Endocrine Neoplasia Type 1 Syndrome
title_full Cushing’s Syndrome Due to a Functional Thymic Neuroendocrine Tumor in Multiple Endocrine Neoplasia Type 1 Syndrome
title_fullStr Cushing’s Syndrome Due to a Functional Thymic Neuroendocrine Tumor in Multiple Endocrine Neoplasia Type 1 Syndrome
title_full_unstemmed Cushing’s Syndrome Due to a Functional Thymic Neuroendocrine Tumor in Multiple Endocrine Neoplasia Type 1 Syndrome
title_short Cushing’s Syndrome Due to a Functional Thymic Neuroendocrine Tumor in Multiple Endocrine Neoplasia Type 1 Syndrome
title_sort cushing’s syndrome due to a functional thymic neuroendocrine tumor in multiple endocrine neoplasia type 1 syndrome
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572323/
https://www.ncbi.nlm.nih.gov/pubmed/34760427
http://dx.doi.org/10.7759/cureus.18590
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