Cargando…

The majority of SARS-CoV-2-specific antibodies in COVID-19 patients with obesity are autoimmune and not neutralizing

BACKGROUND/OBJECTIVES: Obesity decreases the secretion of SARS-CoV-2-specific IgG antibodies in the blood of COVID-19 patients. How obesity impacts the quality of the antibodies secreted, however, is not understood. Therefore, the objective of this study is to evaluate the presence of neutralizing v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frasca, Daniela, Reidy, Lisa, Romero, Maria, Diaz, Alain, Cray, Carolyn, Kahl, Kristin, Blomberg, Bonnie B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572364/ https://www.ncbi.nlm.nih.gov/pubmed/34744161 http://dx.doi.org/10.1038/s41366-021-01016-9

Ejemplares similares

Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients
por: Frasca, Daniela, et al.
Publicado: (2021)

Secretion of autoimmune antibodies in the human subcutaneous adipose tissue
por: Frasca, Daniela, et al.
Publicado: (2018)

Hyper‐metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities
por: Frasca, Daniela, et al.
Publicado: (2021)

Phenotypic and Functional Characterization of Double Negative B Cells in the Blood of Individuals With Obesity
por: Frasca, Daniela, et al.
Publicado: (2021)

Obesity accelerates age defects in B cells, and weight loss improves B cell function
por: Frasca, Daniela, et al.
Publicado: (2023)

Metformin Enhances B Cell Function and Antibody Responses of Elderly Individuals With Type-2 Diabetes Mellitus
por: Frasca, Daniela, et al.
Publicado: (2021)

Metabolic requirements of human pro-inflammatory B cells in aging and obesity
por: Frasca, Daniela, et al.
Publicado: (2019)

Obesity Accelerates Age-Associated Defects in Human B Cells Through a Metabolic Reprogramming Induced by the Fatty Acid Palmitate
por: Frasca, Daniela, et al.
Publicado: (2022)

B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity
por: Frasca, Daniela, et al.
Publicado: (2021)

Obesity Accelerates Age Defects in Mouse and Human B Cells
por: Frasca, Daniela, et al.
Publicado: (2020)

Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination
por: Frasca, Daniela, et al.
Publicado: (2020)

Aging, Obesity, and Inflammatory Age-Related Diseases
por: Frasca, Daniela, et al.
Publicado: (2017)

Phenotypic and functional features of B cells from two different human subcutaneous adipose depots
por: Frasca, Daniela, et al.
Publicado: (2023)

Identification and Characterization of Adipose Tissue-Derived Human Antibodies With “Anti-self” Specificity
por: Frasca, Daniela, et al.
Publicado: (2020)

Effects of age on H1N1-specific serum IgG1 and IgG3 levels evaluated during the 2011–2012 influenza vaccine season
por: Frasca, Daniela, et al.
Publicado: (2013)

Brief Post-Surgical Stress Management Reduces Pro-Inflammatory Cytokines in Overweight and Obese Breast Cancer Patients Undergoing Primary Treatment
por: Ream, Molly, et al.
Publicado: (2022)

AID Activity in B Cells Strongly Correlates with Polyclonal Antibody Affinity Maturation in-vivo Following Pandemic 2009-H1N1 Vaccination in Humans
por: Khurana, Surender, et al.
Publicado: (2012)

Obesity Accelerates Age Defects in Human B Cells and Induces Autoimmunity
por: Frasca, Daniela
Publicado: (2022)

Comments on the evaluation of lymphocyte levels in a random sample of 218 elderly individuals from São Paulo city
por: Blomberg, Bonnie B., et al.
Publicado: (2011)

Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging
por: Frasca, Daniela, et al.
Publicado: (2017)

Impaired B Cell Function in Mice Lacking Perforin-2
por: Frasca, Daniela, et al.
Publicado: (2020)

Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses
por: Frasca, Daniela
Publicado: (2022)

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
por: Cao, Yunlong, et al.
Publicado: (2021)

Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus
por: Wistuba-Hamprecht, Kilian, et al.
Publicado: (2013)

Validation of a SARS-CoV-2 Surrogate Neutralization Test Detecting Neutralizing Antibodies against the Major Variants of Concern
por: Santos da Silva, Eveline, et al.
Publicado: (2023)

Immunogenicity of SARS-CoV: the Receptor-Binding Domain of S Protein is a Major Target of Neutralizing Antibodies
por: He, Yuxian
Publicado: (2006)

Impaired neutralizing antibodies and preserved cellular immunogenicity against SARS-CoV-2 in systemic autoimmune rheumatic diseases
por: Intapiboon, Porntip, et al.
Publicado: (2022)

Potently neutralizing and protective human antibodies against SARS-CoV-2
por: Zost, Seth J., et al.
Publicado: (2020)

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies
por: Hassan, Ahmed O., et al.
Publicado: (2020)

Antibody-mediated neutralization of SARS-CoV-2
por: Gruell, Henning, et al.
Publicado: (2022)

Neutralizing antibodies for SARS-CoV-2 infection
por: Berenguer, Juan
Publicado: (2022)

Neutralizing antiviral antibody responses
por: Zinkernagel, Rolf M., et al.
Publicado: (2001)

Influence of Obesity on Pneumococcus Infection Risk in the Elderly
por: Frasca, Daniela, et al.
Publicado: (2019)

Effects of Obesity on Infections with Emphasis on Skin Infections and Wound Healing
por: Frasca, Daniela, et al.
Publicado: (2022)

Initial Experience With SARS-CoV-2-Neutralizing Monoclonal Antibodies in Kidney or Combined Kidney-Pancreas Transplant Recipients
por: Bachmann, Friederike, et al.
Publicado: (2022)

Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population
por: Zhu, Rui, et al.
Publicado: (2018)

Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers
por: Vanshylla, Kanika, et al.
Publicado: (2022)

Overview of Neutralization Assays and International Standard for Detecting SARS-CoV-2 Neutralizing Antibody
por: Liu, Kuan-Ting, et al.
Publicado: (2022)

Development and characterization of SARS-CoV-2 variant-neutralizing monoclonal antibodies
por: Qiu, Hongyu, et al.
Publicado: (2021)

SARS-CoV-2 neutralizing antibody development strategies
por: BALCIOĞLU, Bertan Koray, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1ohk7kanf7k37jtevg4iegd0b7