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Effect of exposure to antibiotics on the gut microbiome and biochemical indexes of pregnant women

INTRODUCTION: Exposure to antibiotics (ABX) during pregnancy can have a systematic effect on both fetal and maternal health. Although previous biomonitoring studies have indicated the effects on children of extensive exposure to ABX, studies on pregnant women remain scarce. To explore the effect on...

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Autores principales: Su, Yao, Gan, Xu-Pei, Li, Fei-Fei, Zhang, Dong-Yao, Chen, Li, Cao, Yan-Nan, Qiu, Hong-Hui, Cheng, De-Cui, Zu, Jian-Fei, Liu, Wen-Yu, Wang, Hong-Kun, Xu, Xian-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572386/
https://www.ncbi.nlm.nih.gov/pubmed/34732397
http://dx.doi.org/10.1136/bmjdrc-2021-002321
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author Su, Yao
Gan, Xu-Pei
Li, Fei-Fei
Zhang, Dong-Yao
Chen, Li
Cao, Yan-Nan
Qiu, Hong-Hui
Cheng, De-Cui
Zu, Jian-Fei
Liu, Wen-Yu
Wang, Hong-Kun
Xu, Xian-Ming
author_facet Su, Yao
Gan, Xu-Pei
Li, Fei-Fei
Zhang, Dong-Yao
Chen, Li
Cao, Yan-Nan
Qiu, Hong-Hui
Cheng, De-Cui
Zu, Jian-Fei
Liu, Wen-Yu
Wang, Hong-Kun
Xu, Xian-Ming
author_sort Su, Yao
collection PubMed
description INTRODUCTION: Exposure to antibiotics (ABX) during pregnancy can have a systematic effect on both fetal and maternal health. Although previous biomonitoring studies have indicated the effects on children of extensive exposure to ABX, studies on pregnant women remain scarce. To explore the effect on pregnant women of environmental exposure to ABX through accidental ingestion and identify potential health risks, the present study investigated 122 pregnant women in East China between 2019 and 2020. RESEARCH DESIGN AND METHODS: The presence of six categories of ABX (quinolones, sulfonamides, lincosamides, tetracyclines, amide alcohol ABX, and β-lactams) in plasma samples taken from the pregnant women was investigated using an ABX kit and a time-resolved fluorescence immunoassay. RESULTS: All six ABX were detected in the plasma, with a detection rate of 17.2%. It was discovered that the composition of intestinal flora in pregnant women exposed to ABX was different from that of pregnant women who had not been exposed to ABX. The intestinal flora of pregnant women exposed to ABX also changed at both the phylum and genus levels, and several genera almost disappeared. Furthermore, the metabolic levels of glucose and insulin and the alpha diversity of pregnant women exposed to ABX were higher than those of pregnant women not exposed to ABX. CONCLUSION: Pregnant women are potentially at higher risk of adverse microbial effects. Glucose metabolism and insulin levels were generally higher in pregnant women exposed to ABX than in unexposed women. Also, the composition and color of the gut microbiome changed.
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spelling pubmed-85723862021-11-17 Effect of exposure to antibiotics on the gut microbiome and biochemical indexes of pregnant women Su, Yao Gan, Xu-Pei Li, Fei-Fei Zhang, Dong-Yao Chen, Li Cao, Yan-Nan Qiu, Hong-Hui Cheng, De-Cui Zu, Jian-Fei Liu, Wen-Yu Wang, Hong-Kun Xu, Xian-Ming BMJ Open Diabetes Res Care Clinical care/Education/Nutrition INTRODUCTION: Exposure to antibiotics (ABX) during pregnancy can have a systematic effect on both fetal and maternal health. Although previous biomonitoring studies have indicated the effects on children of extensive exposure to ABX, studies on pregnant women remain scarce. To explore the effect on pregnant women of environmental exposure to ABX through accidental ingestion and identify potential health risks, the present study investigated 122 pregnant women in East China between 2019 and 2020. RESEARCH DESIGN AND METHODS: The presence of six categories of ABX (quinolones, sulfonamides, lincosamides, tetracyclines, amide alcohol ABX, and β-lactams) in plasma samples taken from the pregnant women was investigated using an ABX kit and a time-resolved fluorescence immunoassay. RESULTS: All six ABX were detected in the plasma, with a detection rate of 17.2%. It was discovered that the composition of intestinal flora in pregnant women exposed to ABX was different from that of pregnant women who had not been exposed to ABX. The intestinal flora of pregnant women exposed to ABX also changed at both the phylum and genus levels, and several genera almost disappeared. Furthermore, the metabolic levels of glucose and insulin and the alpha diversity of pregnant women exposed to ABX were higher than those of pregnant women not exposed to ABX. CONCLUSION: Pregnant women are potentially at higher risk of adverse microbial effects. Glucose metabolism and insulin levels were generally higher in pregnant women exposed to ABX than in unexposed women. Also, the composition and color of the gut microbiome changed. BMJ Publishing Group 2021-11-03 /pmc/articles/PMC8572386/ /pubmed/34732397 http://dx.doi.org/10.1136/bmjdrc-2021-002321 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Clinical care/Education/Nutrition
Su, Yao
Gan, Xu-Pei
Li, Fei-Fei
Zhang, Dong-Yao
Chen, Li
Cao, Yan-Nan
Qiu, Hong-Hui
Cheng, De-Cui
Zu, Jian-Fei
Liu, Wen-Yu
Wang, Hong-Kun
Xu, Xian-Ming
Effect of exposure to antibiotics on the gut microbiome and biochemical indexes of pregnant women
title Effect of exposure to antibiotics on the gut microbiome and biochemical indexes of pregnant women
title_full Effect of exposure to antibiotics on the gut microbiome and biochemical indexes of pregnant women
title_fullStr Effect of exposure to antibiotics on the gut microbiome and biochemical indexes of pregnant women
title_full_unstemmed Effect of exposure to antibiotics on the gut microbiome and biochemical indexes of pregnant women
title_short Effect of exposure to antibiotics on the gut microbiome and biochemical indexes of pregnant women
title_sort effect of exposure to antibiotics on the gut microbiome and biochemical indexes of pregnant women
topic Clinical care/Education/Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572386/
https://www.ncbi.nlm.nih.gov/pubmed/34732397
http://dx.doi.org/10.1136/bmjdrc-2021-002321
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