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Liver Elastography as a Predictor of Esophageal Varices in Patients With Cirrhosis

Introduction Liver cirrhosis is an advanced consequence of a long-standing liver disease that can lead to portal hypertension which subsequently can manifest as life-threatening variceal bleeding. The present study aimed to determine liver stiffness by shear wave elastography (SWE) to predict esopha...

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Autores principales: Danish, Muhammad, Ismail, Hina, Tulsi, Rani, Mehmood, Nasir, Laeeq, Syed Muddasir, Hassan Luck, Nasir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572475/
https://www.ncbi.nlm.nih.gov/pubmed/34765358
http://dx.doi.org/10.7759/cureus.18593
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author Danish, Muhammad
Ismail, Hina
Tulsi, Rani
Mehmood, Nasir
Laeeq, Syed Muddasir
Hassan Luck, Nasir
author_facet Danish, Muhammad
Ismail, Hina
Tulsi, Rani
Mehmood, Nasir
Laeeq, Syed Muddasir
Hassan Luck, Nasir
author_sort Danish, Muhammad
collection PubMed
description Introduction Liver cirrhosis is an advanced consequence of a long-standing liver disease that can lead to portal hypertension which subsequently can manifest as life-threatening variceal bleeding. The present study aimed to determine liver stiffness by shear wave elastography (SWE) to predict esophageal varices (EV) in patients with chronic liver diseases. Methodology A prospective observational study was performed at the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi between November 2020 and July 2021. Individuals aged between 18 and 50 years, irrespective of gender, with diagnosed chronic liver disease >6 months were eligible to partake in the study. Patients with concomitant renal failure, severe ascites, severe life-threatening co-morbidities including congestive heart failure NYHA-III and IV, acute asthmatic attack, and recent myocardial infarction (MI) were excluded from the study. SWE was determined in all patients to measure liver stiffness. Esophagogastroduodenoscopy (EGD) was performed to visualize the esophageal varices. All findings were recorded. A 2 × 2 table was applied to determine the sensitivity, specificity, positive, and diagnostic accuracy for SWE by taking endoscopy as the definitive test. Results A total of 204 patients were included in the study. Mean age of 40.37 ± 15.20 years was observed. The mean liver size of patients was 12.38 ± 2.06 cm and the mean liver stiffness of patients was 19.97 ± 8.6. The sensitivity and specificity of liver elastography were 44.90% and 51.90%, respectively. Furthermore, the positive and negative predictive values were 53.00% and 99.39%, respectively. The diagnostic accuracy of the test was 51.86%. Conclusion Even though the diagnostic gold standard for the detection of varices is EGD, liver elastography provides a less invasive procedure to assess for varices in patients with cirrhotic liver disease. The present study concluded that liver elastography is a non-invasive and indirect valuable tool to predict the presence of esophageal varices with sensitivity and specificity of 44.90% and 51.90%, respectively.
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spelling pubmed-85724752021-11-10 Liver Elastography as a Predictor of Esophageal Varices in Patients With Cirrhosis Danish, Muhammad Ismail, Hina Tulsi, Rani Mehmood, Nasir Laeeq, Syed Muddasir Hassan Luck, Nasir Cureus Internal Medicine Introduction Liver cirrhosis is an advanced consequence of a long-standing liver disease that can lead to portal hypertension which subsequently can manifest as life-threatening variceal bleeding. The present study aimed to determine liver stiffness by shear wave elastography (SWE) to predict esophageal varices (EV) in patients with chronic liver diseases. Methodology A prospective observational study was performed at the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi between November 2020 and July 2021. Individuals aged between 18 and 50 years, irrespective of gender, with diagnosed chronic liver disease >6 months were eligible to partake in the study. Patients with concomitant renal failure, severe ascites, severe life-threatening co-morbidities including congestive heart failure NYHA-III and IV, acute asthmatic attack, and recent myocardial infarction (MI) were excluded from the study. SWE was determined in all patients to measure liver stiffness. Esophagogastroduodenoscopy (EGD) was performed to visualize the esophageal varices. All findings were recorded. A 2 × 2 table was applied to determine the sensitivity, specificity, positive, and diagnostic accuracy for SWE by taking endoscopy as the definitive test. Results A total of 204 patients were included in the study. Mean age of 40.37 ± 15.20 years was observed. The mean liver size of patients was 12.38 ± 2.06 cm and the mean liver stiffness of patients was 19.97 ± 8.6. The sensitivity and specificity of liver elastography were 44.90% and 51.90%, respectively. Furthermore, the positive and negative predictive values were 53.00% and 99.39%, respectively. The diagnostic accuracy of the test was 51.86%. Conclusion Even though the diagnostic gold standard for the detection of varices is EGD, liver elastography provides a less invasive procedure to assess for varices in patients with cirrhotic liver disease. The present study concluded that liver elastography is a non-invasive and indirect valuable tool to predict the presence of esophageal varices with sensitivity and specificity of 44.90% and 51.90%, respectively. Cureus 2021-10-08 /pmc/articles/PMC8572475/ /pubmed/34765358 http://dx.doi.org/10.7759/cureus.18593 Text en Copyright © 2021, Danish et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Danish, Muhammad
Ismail, Hina
Tulsi, Rani
Mehmood, Nasir
Laeeq, Syed Muddasir
Hassan Luck, Nasir
Liver Elastography as a Predictor of Esophageal Varices in Patients With Cirrhosis
title Liver Elastography as a Predictor of Esophageal Varices in Patients With Cirrhosis
title_full Liver Elastography as a Predictor of Esophageal Varices in Patients With Cirrhosis
title_fullStr Liver Elastography as a Predictor of Esophageal Varices in Patients With Cirrhosis
title_full_unstemmed Liver Elastography as a Predictor of Esophageal Varices in Patients With Cirrhosis
title_short Liver Elastography as a Predictor of Esophageal Varices in Patients With Cirrhosis
title_sort liver elastography as a predictor of esophageal varices in patients with cirrhosis
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572475/
https://www.ncbi.nlm.nih.gov/pubmed/34765358
http://dx.doi.org/10.7759/cureus.18593
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